Obesity
Conditions
Interventions
Two intervention groups will be formed: the high intensity interval training group (GHIIT) and the moderate intensity continuous training group (GMICT), which performed the following protocols for 16
Other
G11.427.410.698.277
I02.233.543
E02.760.169.063.500.387
Sponsors
Universidade Estadual de Maringá
Universidade Estadual de Maringá
Eligibility
Sex/Gender
Female
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: Be female; be between 18 and 35 years of age; present a picture of obesity (BMI: greater than or equal to 30 kg/m²); individuals with body weight stabilized for at least 12 weeks; who have not participated in weight reduction programs before; not suffering from cardiopathies, diabetes and / or hypertension and endocrine diseases; non smokers; who are not making use of medicines that can alter cardiorespiratory and neuromuscular systems; with readiness to participate in evaluations and interventions; and signing of the Informed Consent Form (TCLE).
Exclusion criteria
Exclusion criteria: Volunteers who present in the clinical evaluation and / or laboratory tests any pathology or other complications that may be risk factors or adhesion to the regular practice of the proposed physical activity; and any other condition that could interfere with the test and /or intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome 1 predicted for the present study will be parameters of arterial stiffness (central arterial pressure, carotid-femoral pulse wave velocity and augmentation index). Such measurements will be evaluated by a cardiologist using the SphygmoCor XCEL device (EM4C, AtCor Medical, Sydney, Australia).;The primary outcome 2 predicted for the present study will be parameters of left ventricular systolic function (ejection fraction and overall longitudinal strain). For the evaluation of the measurements, Doppler echocardiographic tests will be performed using an echocardiography / ultrasound device (Vivid T8 model, GE Healthcare, Chicago, Illinois, United States of America) with a transducer (2,7- 8.0 Mhz), as recommended by the American Society of Echocardiography and the European Cardiovascular Imaging Association.;The primary outcome 3 predicted for the present study will be parameters of the diastolic function of the left atrium (longitudinal strain). Echocardiographic Doppler examinations will be performed with an echocardiography / ultrasound device (Vivid T8 model, GE Healthcare, Chicago, Illinois, United States of America) with a transducer (2.7-8.0 Mhz), as recommended by the American Society of Echocardiography and the European Cardiovascular Imaging Association. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcome 1 predicted for the present study will be the (complete blood count, lipid profile, glycemia and insulinemia). Blood samples will be collected after a fast of 12 hours in the morning by a qualified professional, through venipuncture in blood tubes with gel, to obtain serum and EDTA. For the calculation of insulin resistance, Homeostasis Model Assessment (HOMA-IR) described by Matthewset al. (1985), whereas for the calculation of insulin sensitivity the Quantitative Insulin Sensitivity Check Index (QUICKI), described by Katz et al. (2000).;The secondary outcome 2 planned for the inflammatory parameters changes (ultra-sensitive C-reactive protein, adiponectin and leptin). For the determination of the inflammatory markers, the ELISA (solid phase immunoenzymatic assay) according to the specifications of the high sensitivity kits (R & D Systems, Minneapolis, USA) will be used. All determinations of circulating cytokine and adipokine concentrations will be performed in duplicate. The nitric oxide (NOx) levels in the sample will be prepared based on the enzymatic conversion of nitrate to nitrite by the enzyme nitrate reductase (Griess Reaction), according to the description of the Nitrate / Nitrite Colorimetric Assay Kit (R & D Systems , Minneapolis, USA) and analyzed by the ELISA method (solid phase immunoenzyme assay).;The secondary outcome 3 planned for the present study will be the changes in the anthropometric parameters (Body mass, BMI and waist circumference). The body mass will be measured in a mechanical anthropometric scale (Filizola®), with an accuracy of 0.1 kg and a maximum capacity of 150 kg. Body mass index (BMI) will be calculated by the ratio of body mass to height squared. The waist circumference will be measured with an inelastic tape measure (Sanny®), with resolution of 0.1 cm and amplitude of 2 m, with the participant fasting in the orthostatic position at the midpoint between the last rib and the iliac crest.;The secondary ou | — |
Countries
Brazil
Contacts
Public ContactCaroline ;Gustavo Henrique Simões;de Oliveira
Caroline Ferraz Simões;Universidade Estadual de Maringá
Outcome results
None listed