COVID-19
Conditions
Interventions
A pulmonary rehabilitation (PR) program associated with the use of noninvasive ventilation (NIV) will be conducted in individuals with COVID-19 after the severe form (post-COVID-19 syndrome). 100 indi
E02.041.625.591
Sponsors
Universidade Federal do Amazonas
Universidade Federal do Amazonas
Eligibility
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: Clinically stable individuals, residing in Manaus must have been diagnosed with COVID-19 by the polymerase chain reaction method (RT-PCR) for SARS-CoV-2, remained hospitalized and had discharged from the hospital. In addition, volunteers must present a pre-hospitalization medical history of clinical stability in the 4 months before hospitalization for COVID-19 and perception of dyspnea II and III by the Medical Research Council (MRC).
Exclusion criteria
Exclusion criteria: Volunteers undergoing pulmonary rehabilitation 6 months before the start of the study, pregnant women, previous medical history of respiratory diseases (COPD, asthma, idiopathic pulmonary fibrosis), arterial O2 saturation (SpO2) = 88% at rest, hypertension uncontrolled, cardiovascular (heart failure, hypertension, transplantation, and surgeries), history of use and abuse of illicit drugs, alcoholics, smokers, pacemakers and/or implantable defibrillators, oncologic, metabolic (diabetes) and decompensated, chronic-degenerative kidneys in progression and osteoarticular and cognitive that prevent the performance of the physical exercise. In addition, individuals who present claustrophobia to the use of the NIV mask for training or performing the cardiopulmonary test will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improved V?O2 through cardiopulmonary test, distance walked in the 6-minute walk test, and quality of life through SF-36 values | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of spirometric variables, cytokine quantification, arterial endothelial function, HbO2 consumption behavior, HHb production, total hemoglobin and tissue saturation index during exercise, heart rate variability, the sequelae prevalence, the maintenance time of the primary and secondary clinical outcomes and, the number of admissions and deaths within 12 months after hospital discharge. | — |
Countries
Brazil
Contacts
Public ContactGuilherme Arêas
Outcome results
None listed