Nitroglycerin
Conditions
Interventions
Randomized controlled trial comparing two vasodilatory strategies in the treatment of acute pulmonary edema, including a total of 150 participants. Participants will be randomized through opaque seale
s clinical response. The study is open-label, meaning that both researchers and participants will know which medication is being administered, as knowledge of the medication is necessary for appropria
Sponsors
Santa Casa de Misericórdia da Bahia
Santa Casa de Misericórdia da Bahia
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with diagnosis of acute pulmonary edema in the emergency unit requiring vasodilator; age 18 years or older; both genders
Exclusion criteria
Exclusion criteria: Patients under 18 years of age; patients with cardiogenic shock; patients with acute coronary syndrome; patients with contraindication to any of the drugs; pregnant patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the efficacy of nitroglycerin versus sodium nitroprusside in the management of acute pulmonary edema in adults, verified by comparative analysis of all clinical parameters between T0 and T6h, using measurements of respiratory rate, use of accessory muscles, oxygen saturation, systolic and diastolic blood pressure, ventilatory support, ventilatory pattern and pulmonary ultrasound (POCUS), observing statistically significant difference between groups in the improvement of clinical and radiological parameters | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the time to resolution of respiratory symptoms between the two treatment groups, verified by comparative analysis of progressive clinical evolution during the 6-hour protocol, using respiratory rate, oxygen saturation, use of accessory muscles and changes in ventilatory support, observing statistically significant difference in resolution time between nitroglycerin and sodium nitroprusside; to compare the incidence of serious adverse events (hypotension and arrhythmias) related to drug use, verified by continuous recording during the 6-hour protocol, using measurements of systolic and diastolic blood pressure at T0, T1h, T2h and T6h and monitoring of cardiac rhythm disturbances, observing statistically significant difference in the frequency and severity of hypotension and arrhythmias between groups | — |
Countries
Brazil
Contacts
Public ContactAna Beatriz Carvalho
Santa Casa de Misericórdia da Bahia
Outcome results
None listed