Assessment of the effects of Transcranial Magnetic Stimulation associated with Inspiratory Muscle Training on sleep quality in individuals with Obstructive Sleep Apnea

Effects of Transcranial Magnetic Stimulation on Inspiratory Muscle Training and its impacts on sleep quality of individuals with Obstructive Sleep Apnea: a cross-over study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-3t5mq88

Enrollment

Registered

2026-07-01

Start date

2026-11-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea Sleep Wake Disorders

Interventions

This is a randomized, controlled, double-blind clinical trial with a two-period, two-sequence crossover design. A total of 30 participants diagnosed with obstructive sleep apnea will be recruited, and

Eligibility

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Individuals with a previous diagnosis of obstructive sleep apnea; both sexes; aged between 18 and 65 years

Exclusion criteria

Exclusion criteria: History of seizures; body mass index consistent with class II obesity; presence of cochlear implants or metallic implants in the cranial region; orthopedic or cognitive impairments that preclude completion of the study procedures; presence of other respiratory diseases

Design outcomes

Primary

Measure	Time frame
An improvement in sleep efficiency is expected following the intervention periods. Sleep efficiency will be assessed by actigraphy, with measurements performed at baseline and at the end of each intervention period. Improvement will be defined as an increase of at least 5% in sleep efficiency (%) compared with baseline values and the placebo condition.;A reduction in hypoxic burden is expected following the intervention periods. Hypoxic burden will be assessed by overnight pulse oximetry using the oxygen desaturation index and cumulative oxygen desaturation parameters, with measurements performed at baseline and at the end of each intervention period. Improvement will be defined as a reduction in the oxygen desaturation index and cumulative oxygen desaturation parameters compared with baseline values and the placebo condition.	—

Measure

Time frame

An improvement in sleep efficiency is expected following the intervention periods. Sleep efficiency will be assessed by actigraphy, with measurements performed at baseline and at the end of each intervention period. Improvement will be defined as an increase of at least 5% in sleep efficiency (%) compared with baseline values and the placebo condition.;A reduction in hypoxic burden is expected following the intervention periods. Hypoxic burden will be assessed by overnight pulse oximetry using the oxygen desaturation index and cumulative oxygen desaturation parameters, with measurements performed at baseline and at the end of each intervention period. Improvement will be defined as a reduction in the oxygen desaturation index and cumulative oxygen desaturation parameters compared with baseline values and the placebo condition.

—

Secondary

Measure	Time frame
A reduction in excessive daytime sleepiness is expected after the intervention periods. Excessive daytime sleepiness will be assessed using the Epworth Sleepiness Scale, with measurements performed at baseline and at the end of each intervention period. Improvement will be considered when a reduction in the total ESS score is observed compared with baseline values and the placebo condition	—

Countries

Contacts

Public ContactRoberta Cristiane da Silva

Departamento de Fisioterapia da Universidade federal de Pernambuco

departamentodefisioterapia@ufpe.br+55 (81) 2126-8492

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Aug 10, 2026