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Evaluation of the inflammation and effects of dental denture during orthodontic treatmen

Evaluation of inflammatory activity and efficacy of dental bleaching during orthodontic treatment: a randomized clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-3sqsh8
Enrollment
Unknown
Registered
2018-07-09
Start date
2018-05-11
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthodontic brackets

Interventions

Control group (G1): 10 patients will receive office dental bleaching using 35% hydrogen peroxide agent
Control group (G2): in 10 patients orthodontic brackets will be bonded in the upper premolars in a period of 67 days
Experimental group (G3): in 10 individuals will be bonded orthodontic brackets in the upper premolars, after a period of 30 days will receive dental bleaching in the office, with a 35% hydrogen peroxi
Procedure/surgery
E06.420.750

Sponsors

Centro Universitário do Maranhão
Lead Sponsor
Centro Universitário do Maranhão
Collaborator

Eligibility

Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Patients aged between 18 and 40 years will be included; who agree and sign the informed consent form (TCLE); with good oral health in general, with the presence of all upper teeth up to the first molar with vitality, free of caries lesions; and may have satisfactory aesthetic restorations, proven by periapical radiographs that do not involve the middle third of the dental crown; without cervical lesions (abrasion, erosion and abduction); absence of periodontal disease; have not undergone periodontal treatment within 3 months prior to the start of the study; do not present clinical signs of gingivitis and do not have systemic disorders that interfere with the periodontal condition, prior to the installation of the device; non smokers; have not undergone previous orthodontic treatment; have not used antibiotics in the 3 months prior to the study; not being on systemic medication; the initial color of the teeth should be A2 or darker by comparison with the Vita Classic scale (Vita Zahnfabrik, Bad Säckingen, Germany) organized in order of value

Exclusion criteria

Exclusion criteria: The study will exclude patients who had undergone tooth whitening treatment in the last 12 months; with caries, cervical lesions; pregnant or lactating women; root canal treatment; patients with restorations at buccal surface or dental prosthesis on the teeth; gingival recessions; parafunctional habits; patients who were taking medications with an analgesic or anti-inflammatory effect

Design outcomes

Primary

MeasureTime frame
The increase in the inflammatory activity, determined by quantification of the volume of gingival fluid measured in the phases: pre and post bleaching;The increase in the inflammatory activity, determined by evaluation of the proinflammatory cytokine levels, measured in the phases: pre and post bleaching

Secondary

MeasureTime frame
Enamel color changes under orthodontic brackets bonded to superior premolars submitted to dental bleaching during orthodontic treatment

Countries

Brazil

Contacts

Public ContactCélia;Edson Maio Pinzan Vercelino;Pereira Barbosa

Universidade CEUMA - UniCEUMA;Universidade CEUMA - UniCEUMA

cepinzan@hotmail.com;egustavob@gmail.com+5509832144277;+5509832144277

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 10, 2026