Shock Septic Mortality
Conditions
Interventions
This is a double-blind, randomized clinical trial. Eligible patients will be divided into two groups through randomization in blocks of 6 patients. Randomization will be performed by a researcher who
randomizer"
mobile application. The intervention group (54 participants) will receive 5 mg of intravenous Haloperidol every 12 hours for 3 days within 24 hours of hospital admission. The placebo group (54 partici
Sponsors
Universidade Estadual Paulista
Universidade Estadual Paulista
Eligibility
Age
19 Years to No maximum
Inclusion criteria
Inclusion criteria: The inclusion criteria will be individuals over 18 years of age, of both sexes, admitted with a diagnosis of septic shock and on mechanical ventilation (MV) to the Intensive Care Unit of the Hospital das Clínicas of the Faculty of Medicine of Botucatu (HC/FMB) between March 2026 and February 2028
Exclusion criteria
Exclusion criteria: Pregnant women, patients with brain death or in palliative care, those with other types of shock (cardiogenic, hemorrhagic), those with a prolonged QTc interval on the electrocardiogram (greater than or equal to 450 ms for men and greater than or equal to 470 ms for women), as well as those whose legal representative/family member does not consent to participation by signing the Informed Consent Form (ICF), will be excluded
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the occurrence of hospital mortality, verified through the registration of death in the institutional electronic medical record during the period of hospital stay, with the outcome being considered when the participant's death is observed during hospitalization, expressed as an absolute number and percentage of deaths in each study group | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the duration of vasoactive drug use during hospital stay, verified through prescription and progress notes in the institutional electronic medical record, analyzing the total time of use of these medications during hospitalization, expressed in number of hours or days of use in each study group | — |
Countries
BR
Contacts
Public ContactLetycia Cunha
Universidade Estadual Paulista
Outcome results
None listed