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Effects of acute supplementation with extract from the bark of the Maritime Pine tree, alone or combined with Yohimbine, on muscle strength, heart and lung capacity during exercise, and blood markers of muscle damage in healthy adults: a randomized, double-blind clinical trial

Effects of acute supplementation with Pinus Pinaster alone or combined with Yohimbine on muscle strength, cardiorespiratory fitness, and muscle damage biomarkers in healthy adults: a randomized, double-blind clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-3rxr4bj
Enrollment
Unknown
Registered
2025-11-06
Start date
2025-06-20
Completion date
Unknown
Last updated
2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Biomarkers, Pharmacological

Interventions

This is a randomized, double-blind clinical trial. A total of 40 eligible participants will be probabilistically allocated into three intervention groups using a random number table. Both the research
another group of ten healthy male participants receiving 150 mg/day of Pinus Pinaster combined with 5 mg/day of Yohimbine
and a third group of ten healthy male participants receiving only 5 mg/day of Yohimbine. The control group will include ten healthy male participants receiving oral supplementation of corn starch (pla

Sponsors

União Brasileira de Educação e Assistência
Lead Sponsor
União Brasileira de Educação e Assistência
Collaborator

Eligibility

Sex/Gender
Male
Age
20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Adult male bodybuilders; age 20 to 45; who have been bodybuilding for at least six months; practitioners who include at least three weightlifting physical activity sessions per week

Exclusion criteria

Exclusion criteria: Individuals diagnosed with any chronic disease or condition such as hypertension ; type 1 or type 2 diabetes mellitus ; as well as those using dietary supplements or medications

Design outcomes

Primary

MeasureTime frame
It is expected to find, with supplementation of Yohimbine and Pinus pinaster, an improvement in muscle strength through the one-repetition maximum test (in the exercises: bench press and biceps curl), blood biomarkers of muscle damage such as total creatine phosphokinase, lactate dehydrogenase, C-reactive protein, and capillary lactate. An improvement in cardiorespiratory fitness is also expected, analyzed by the calculation of maximal oxygen consumption through a submaximal treadmill running test—

Secondary

MeasureTime frame
As secondary outcomes, we expect to find a reduction in resting blood pressure, which will be measured by sphygmomanometer, resting heart rate, measured by smartwatch, and the subjective perception of effort during submaximal exercise. We will also evaluate body composition parameters through skinfold measurements to analyze whether there were any changes in body fat percentage and muscle mass of the participants—

Countries

Brazil

Contacts

Public ContactGiuseppe Stefani

Pontifícia Universidade Católica do Rio Grande do Sul

giuseppe.stefani@pucrs.br+55 (51)33203345

Outcome results

None listed

Source: REBEC (via WHO ICTRP)