Iron
Conditions
Interventions
This is a prospective non-randomized study in which patients with chronic kidney disease on hemodialysis 3 times a week who had serum ferritin > 1000 ng/ml were invited to participate in this study. T
D02.092.570.394.265
Sponsors
Hospital das Clinicas da Universidade de Sao Paulo
Hospital das Clinicas da Universidade de Sao Paulo
Eligibility
Inclusion criteria
Inclusion criteria: Adult patient on maintenance hemodialysisl; serum ferritin higher than 1000 ng/ml
Exclusion criteria
Exclusion criteria: Active smoking; Active use of alcohol; Previous use of desferoxamine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Found outcome 1: There was a significant decrease in serum iron, transferrin saturation, and ferritin after one year, evaluated through magnetic resonance imaging, although 9 patients (45%) remained with a ferritin level higher than that preconized. Eighteen patients (90%) improved liver accumulation. Regarding the iliac crest, all patients improved and reached normal values. There was no iron accumulation in the heart.;Expected outcome 1: We expected to find a significant (p<0.05) reduction on iron storage in the heart, liver and bones, evaluated by magnetic resonance imaging from baseline to one year | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 2: We expected to find a change in bone remodelling;Found outcome 2: There was no change in bone remodelling, mineralization or volume. | — |
Countries
Brazil
Contacts
Public ContactVanda Jorgetti
Hospital das Clinicas da Universidade de Sao Paulo
Outcome results
None listed