Severe periodontitis
Conditions
Interventions
All patients will receive non-surgical periodontal treatment, which consist of supragingival scaling planing and scaling and root planing (SRP) (also known as dental scaling). Furthermore, in the end
Drug
Procedure/surgery
E06.721.189.350
Sponsors
Universidade Federal do Rio Grande do Sul
Universidade Federal do Rio Grande do Sul
Eligibility
Age
30 Years to 60 Years
Inclusion criteria
Inclusion criteria: Man and women between 30 to 60 years of age; Availability to participate in all study phases; Good general health; At least 10 natural teeth, except for the third molars; Diagnosis of severe periodontitis according to Eke et al. (2012), which is at least one interproximal site with probing depth >5mm and clinical attachment loss >6mm in at least two interproximal sites and in different teeth; At baseline, report the use of any statin for at least 3 months;
Exclusion criteria
Exclusion criteria: Presence of orthodontic bands any type of fixed orthodontic appliance; Tumor (s) of soft or hard tissues of the oral cavity; Use of antibiotics 3 months prior to study begging; Pregnant or lactating women; Diagnosis or treatment for diabetes and renal chronic diseases, or any history of stroke; Need to use antimicrobial chemoprophylaxis to receive dental treatment; Had received periodontal treatment in the last 6 months; Current smokers or former smokers in less than 2 years; Body mass index >30 kg/m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Clinical attachment level (CAL) will be measured in 6 sites per tooth. All tooth will be evaluated, except for third molars. This measurement comprised the distance, in milimeters, from the bottom of the periodontal pocket until the cemento-ennamel juntion. The changes the occur from the baseline appointment to the 3, 6, 9, 12, and 24-months appoitment in will recorded. Mean and standar deviation from the CAL change will be reported to each patient and each experimental group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Similarly to clinical attachment level, the pocket depth and bleeding on probing will be measured in 6 sites per tooth. Regarding pocket depth, the mean change, in milimiter, of the distance of the gingival margin until the bottom of the periodontal pocket will be determined to each patient/each experimental group. Regarding bleeding on probing, the mean change in the percentage of sites with subgingival bleeding will be determined to each patient/each experimental group. To both parameters, the changes between the baseline appoitment and the re-call appoitments (3, 6, 9, 12, and 24 months) will be considered. Furthermore, the alveolar bone level changes, in milimeters, assessed by pradonized periapical radiographs, will be considered. The comparisons will be performed between the initial radiography and the re-call radiographies (6, 12, and 24 months) will be considered. Changes in the total cholesterol, HDL, LDL e triglycerides will be also determined by the comparison of the initial examination and the follow-up examinations (3, 6, 12, and 24 months). To all secondary outcomes, the values will be reported in mean and standard deviation to each pacient/experimental group. | — |
Countries
Brazil
Contacts
Public ContactCassiano;Francisco Wilker Rosing;Muniz
Universidade Federal do Rio Grande do Sul;Universidade Federal do Rio Grande do Sul
Outcome results
None listed