Dental Pulp Necrosis
Conditions
Interventions
This is a clinical-laboratory study, consisting of two phases. In the first, patients will be randomly divided into two experimental groups (G1 – instrumentation until patency with Reciproc Blue R25
G2 – instrumentation with Reciproc Blue R25, followed by foraminal enlargement with overinstrumentation. Microbiological collections will be carried out after odontometry - control
after R25
after foraminal enlargement
and after seven days. Cytokine collections from the periapical fluid will be carried out immediately after all root canal preparation and after seven days. Postoperative pain will be assessed three ti
Sponsors
Faculdade de Odontologia da Universidade Federal de Minas Gerais
Faculdade de Odontologia da Universidade Federal de Minas Gerais
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients aged 18 years or over; of both sexes; diagnosed with pulp necrosis and apical periodontitis in upper or lower first and/or second molars
Exclusion criteria
Exclusion criteria: Use of some antibiotics and anti-inflammatory drugs in the three months before endodontic therapy; those who have already started instrumentation of the canals previously and/or present concomitant periodontal involvement in the tooth in question; teeth with root fractures, fused roots, incomplete rhizogenesis, wide foramina whose initial apical instrument in the MV canal is greater than K #20
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The reduction in intraradicular bacterial load after root canal instrumentation will be analyzed using molecular detection methods (real-time PCR).;We will observe the expression of inflammatory cytokines, through analysis using molecular detection methods (real-time PCR).;The incidence of postoperative pain after root canal instrumentation will be analyzed, using a five-level scale. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes are expected. | — |
Countries
Brazil
Contacts
Public ContactAna Cecília Viana
Faculdade de Odontologia da Universidade Federal de Minas Gerais
Outcome results
None listed