Diabetes Mellitus Type 2
Conditions
Interventions
Selection of possible research participants will take place the day before the consultation with an endocrinologist through the analysis of the patients' charts. People who meet the elective criteria
Sponsors
Universidade Federal de São Paulo
Universidade Estadual Paulista "Julio Mesquita Filho"
Eligibility
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Volunteers with Type 2 Diabetes Mellitus; patients at the Birigui Specialty Center, São Paulo; both genders; age between 40 and 70 years
Exclusion criteria
Exclusion criteria: Volunteers with walking difficulties and/or who cannot get on the platform scale; current or recent use of antibiotics and anti-inflammatories (3 months); who make or have recently used (last 6 months) Curcuma longa in the form of encapsulated powder, dry vegetable extract, vegetable tincture or other pharmaceutical presentation; recent use (6 months) of plant-derived antioxidant supplements or multivitamins and minerals; volunteers using medications that alter coagulation characteristics such as antiplatelet agents, anticoagulants, low molecular weight heparin and thrombolytic agents; individuals with gallstones or biliary tract obstruction; carriers of autoimmune diseases; inflammatory diseases; infectious diseases; chronic kidney disease; gastric ulcers; liver diseases; cancer; acquired immunodeficiency syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find significant differences in biochemical and salivary markers after the intervention in the curcuma group compared to the placebo group with regard to protein dosages; thiobarbituric acid reactive substances (TBARS); carbonylated proteins; catalase activity in erythrocytes, superoxide dismutase activity in erythrocytes, plasma, erythrocyte and salivary antioxidant potential; plasma and salivary nitrites; superoxide anion and plasma hydrogen peroxide; circulating levels of Endocan; circulating levels of ADMA (Asymmetrical Dimethyl-L-arginine); circulating levels of FGF-23, IL-6, IL-1ß and TNF-a; acid and alkaline phosphatase in saliva; and concentration of calcium and phosphorus in saliva.;It is expected to find improvements in neuropathic symptoms through the Neuropathic Symptom Score (NSS) comparing the beginning of the intervention with the moment after it.;Improvements are expected to be observed after the intervention of oral alterations through clinical examination performed by a dental surgeon, previously calibrated and trained, following the guidelines published in the SB2000 Project Examiner's Manual by the Ministry of Health. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to find good adherence to the herbal medicine Curcuma longa and a low incidence of reports of side effects due to supplementation. | — |
Countries
Brazil
Contacts
Public ContactDrielly Viudes
Universidade Federal de São Paulo
Outcome results
None listed