Chikungunya Fever
Conditions
Interventions
Design: a prospective cohort
Follow-up period: 3 years
Research Procedures and Conduct
Patients arriving at recruiting centers with suspected cases of Dengue (DENV), Zika (ZIKV) or
Chikungunya (CHIK
D90
D120
D180
D360
D720
D1080 days. On these visits,
the same instruments will be applied and biological samples collected.
Unscheduled visits for the purpose of the study will be made under the following
conditions:
a) wors
b) management any adverse event
c) decompensation of an underlying disease
d) at the discretion of the study team (eg reevaluation).
On these unscheduled visits, in addition to the instruments defined for the
scheduled visits, a questionnaire will be applied which contemplat
Other
H01.770.644.145.360
Sponsors
Instituto Nacional de Infectologia Evandro Chagas/Fundacao Oswaldo Cruz (INI/Fiocruz)
Departamento de Ciência e Tecnologia do Ministério da Saúde
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age equals or more than 18 years; patients with recent fever, less than 10 days, with suspected CHIKV, ZIKV or DENV; patients with arthralgia after having a fever, more than 10 days, with suspected CHIKV, ZIKV or DENV
Exclusion criteria
Exclusion criteria: Patients unavailable to attend follow-up at the centers; presence of overt fever from a supposed non-viral origin (eg, cellulitis and abscess); patients with severe mental disorders or from whom the collection of information is not possible due to communication disorders or lack of fluency in Portuguese or another language understood by the attending physician; pregnant or lactating patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect to evaluate the natural history and therapeutic response of musculoskeletal manifestations of patients affected by CHIKV in the Brazilian territory | — |
Secondary
| Measure | Time frame |
|---|---|
| We expect to evaluate the clinical manifestations of CHIKV infection and its evolution in patients in different states of the Brazilian territory;We expect to investigate the risk and prognostic factors associated with the severity and persistence of clinical manifestations, focusing on musculoskeletal changes and chronicity rates;We expect to estimate the socioeconomic, labor, and psychosocial impact of CHIK infection;We expect to perform differential diagnosis between CHIKV, ZIKV, and DENV by real-time multiplex polymerase chain reaction in acute cases;We expect to evaluate the positivity rates for CHIKV by RT-PCR in whole blood, plasma and serum at different stages of infection to establish protocols based on the best positivity rates;We expect to establish the prevalence, viral load and duration of CHIKV infection in different body fluids at different stages of infection, contributing to the elucidation of viral kinetics (pathophysiology or natural history) in different body fluids;We expect to evaluate possible windows for diagnostic possibilities and follow-up of infection in different biological fluids;We expect to establish possible cell lines in which CHIKV may present cell tropism, based on saliva and urine analyses;We expect to correlate the immunological and virological aspects with the clinical manifestations of CHIK patients;We expect to constitute a biorepository of clinically well-characterized samples that can be shared for the evaluation of diagnostic tests and biomarkers that advance the understanding and better clinical and therapeutic management of patients with CHIKV | — |
Countries
Brazil
Contacts
Public ContactJosé Moreira
Instituto Nacional de Infectologia Evandro Chagas/Fundacao Oswaldo Cruz (INI/Fiocruz)
Outcome results
None listed