Intermittent Claudication
Conditions
Interventions
Control intervention: 15 men with intermittent claudication will undergo for 12 weeks and twice a week, 30 minutes of stretching classes.
Walking training intervention: 15 men with intermittent claudi
Other
F01.145.632
Sponsors
Escola de Educação Física e Esporte da Universidade de São Paulo
Ambulatório de Claudicação Intermitente do Hospital das Clínicas Faculdade de Medicina da Universidade de São Paulo
Programa de Promoção de Envelhecimento Saudável do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
Eligibility
Sex/Gender
Male
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: Men; Age between 50 and 80 years; Ankle-brachial index < 0.90 at rest in 1 or 2 legs; Patients with Fontaine stage II symptoms; Able to walk for at least 2 min at 3.2 km/h on a treadmill; Not users of peripheral vasodilators, clopidogrel, beta blockers or nondihydropyridine calcium channel blockers.
Exclusion criteria
Exclusion criteria: Presence of muscle or skeletal disorders that precludes exercise execution; systolic and/or diastolic, respectively, greater than 140 and 90 mmHg; obesity level II or greater; Presence of complex arrhythmias and/ or ischemia during exercise
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of the oxidative stress and systemic inflammation measured by lipid peroxidation and interleukin-6 using ELISA Kits, with minimal reduction of 1.08 nmol/ml and 0.55 nmol/ml, respectively, between initial and final evaluations. | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction of the oxidative stress and muscle inflammation evaluated by catalase increase and intercellular adhesion molecule decrease, respectively, evaluated by genic expression, with minimal increase of 0.07 arbitrary units and reduction of 32.8 arbitrary units, respectively, between initial and final evaluations; Blood pressure decrease verified by auscultatory technique with a minimal reduction of 4 mmHg between initial and after assessments; Heart rate decrease assessed by electrocardiogram with a minimal reduction of 4 bpm between the beginning and end of the study; improve of cardiac and vasomotor autonomic modulation verified by the increase of heart rate modulation and decrease of blood pressure modulation assessed by spectral analysis technique. | — |
Countries
Brazil
Contacts
Public ContactClaudia Forjaz
Escola de Educação Física e Esporte da Universidade de São Paulo
Outcome results
None listed