Comparison of the application of photobiomodulation and high-power laser therapy associated with physiotherapy in the rehabilitation of patients with Leprosy

Comparison of the application of photobiomodulation and high-power laser therapy associated with physiotherapy in the rehabilitation of patients with Leprosy: pragmatic, randomized, triple-blind and placebo-controlled clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-3p9wphq

Enrollment

Registered

2026-05-25

Start date

2026-05-25

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Leprosy Rehabilitation

Interventions

Pragmatic, randomized, triple-blind, placebo-controlled clinical trial. Sample: Based on a previous study that investigated the efficacy of a physiotherapy protocol combined with photobiomodulation tr

this will be the only researcher aware of the group allocation and will not participate in the evaluation or application of the therapies. Physiotherapists responsible for applying the therapies will

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients diagnosed with leprosy who present neuritis; Age over 18 years;

Exclusion criteria

Exclusion criteria: Subjects diagnosed with carcinoma; Pregnant women; Individuals under 18 years of age; Patients who report alcohol consumption more than 3 times a week; Patients diagnosed with diabetes mellitus; Patients with previous lesions unrelated to leprosy.

Design outcomes

Primary

Measure	Time frame
Primary outcome: As a primary outcome, we will evaluate the impact of therapies on the peripheral nervous system, analyzing muscle strength, sensitivity and neural palpation, for this we will use the Simplified Neurological Assessment (ANS) scale.	—

Secondary

Measure	Time frame
As a secondary outcome, we will evaluate neuropathic pain through the visual analog scale;Physical functionality, through an activity limitation and safety awareness screening (SALSA);The electrical conductivity of some peripheral nerves (ulnar nerve: the electrodes are positioned over the abductor muscle of the fifth finger; median nerve: the electrodes are placed over the abductor pollicis brevis muscle; radial nerve: the electrodes are positioned over the extensor muscles of the wrist; common peroneal nerve: electrodes placed over the tibialis anterior muscle, responsible for ankle dorsiflexion; posterior tibial nerve: electrodes over the extensor hallucis longus muscle), evaluated through electroneuromyography ;muscle oxygenation and blood perfusion, which will be evaluated through near-infrared spectroscopy (NIRS);Local body temperature through thermography.	—

Measure

Time frame

As a secondary outcome, we will evaluate neuropathic pain through the visual analog scale;Physical functionality, through an activity limitation and safety awareness screening (SALSA);The electrical conductivity of some peripheral nerves (ulnar nerve: the electrodes are positioned over the abductor muscle of the fifth finger; median nerve: the electrodes are placed over the abductor pollicis brevis muscle; radial nerve: the electrodes are positioned over the extensor muscles of the wrist; common peroneal nerve: electrodes placed over the tibialis anterior muscle, responsible for ankle dorsiflexion; posterior tibial nerve: electrodes over the extensor hallucis longus muscle), evaluated through electroneuromyography ;muscle oxygenation and blood perfusion, which will be evaluated through near-infrared spectroscopy (NIRS);Local body temperature through thermography.

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Countries

Contacts

Public ContactThiago De Marchi

Centro de Excelência em Empreendedorismo e Inovação - CE²I

thiagomarchi@gmail.com+55(54)999044768

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Jun 11, 2026