Use of a dual-action gel to reduce pain caused by dental bleaching performed by the dentist

Management of in-office bleaching-induced tooth sensitivity using a dual-action desensitizing agent: a randomized, triple-blind, split-mouth controlled clinical trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-3nk4685

Enrollment

Registered

2026-03-19

Start date

2026-03-03

Completion date

Unknown

Last updated

2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Bleaching Dentin Sensitivity

Interventions

This is a randomized, controlled, triple-blind, split-mouth clinical trial involving a total number of 54 participants, where each participant will have 2 study arms (both upper hemi-arches), totaling

Eligibility

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Individuals aged between 18 and 50 years ; good general systemic and oral health status ; presence of at least six sound upper anterior teeth, without caries or restorations ; shade corresponding to A2 or darker on the canine, according to the Vita Classical scale ; no history of previous dental bleaching

Exclusion criteria

Exclusion criteria: Use of dental prostheses or orthodontic appliances ; presence of severe tooth staining due to tetracycline, fluorosis, trauma, or pulp necrosis ; pregnant or lactating women ; clinical history of bruxism, gingival recession, visible dentin exposure, or extensive cracks ; current or past systemic diseases affecting the stomach, heart, kidneys, or liver ; continuous use of anti-inflammatory and/or analgesic drugs ; history of allergy to codeine, calcium phosphate, or any component of the tested nanogel

Design outcomes

Primary

Measure	Time frame
To evaluate whether the topical application of codeine and calcium phosphate nanogel reduces the risk and/or intensity of tooth sensitivity induced by bleaching with 35% hydrogen peroxide. Sensitivity will be monitored daily for 14 days using a 5-point Numerical Scale and a 10 cm Visual Analogue Scale.	—

Secondary

Measure	Time frame
To verify the impact of the nanostructured gel on tooth color change after bleaching, confirming that the intervention does not jeopardize the bleaching efficacy. Color will be analyzed subjectively with the Vitapan Classical scale and objectively using a spectrophotometer. The occurrence of adverse effects will also be investigated.	—

Countries

Contacts

Public ContactAnderson Lima-Maniçoba

Universidade Federal do Rio Grande do Norte

kaianp@hotmail.com+55 (84) 99858-2652

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Apr 4, 2026