Facial ageing
Conditions
Interventions
A clinical pilot crossover study of Phase II.
Control and experimental interventions were performed in the same individual, the left side being the placebo and the right the platelet-rich plasma.
Ex
Biological/vaccine
Sponsors
Centro de Hematologia e Hemoterapia - HEMOCENTRO
Universidade Estadual de Campinas
Faculdade de Ciências Médicas
Eligibility
Sex/Gender
Female
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: Healthy volunteers; women; non-smokers; age between 40 and 65 years; Glogau grade II or III photoaging; Fitzpatrick phototype I-IV
Exclusion criteria
Exclusion criteria: Volunteers smoking; history of alcohol or drug abuse; pregnant or in the puerperium; facial aesthetics with absorbent material (hyaluronic acid), laser use in the last year, use of retinoic acid, application of botox or filling and surgical procedures; patients with a history of photosensitivity and of keloid or hypertrophic scar; patients with lesions of infected or inflamed skin on the face in the last year; underlying diseases such as uncontrolled hypertension, liver disease, renal, haematological, inflammatory, rheumatologic, diabetes; patients who have or have had dysplasias;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find an amplified rejuvenating effect on PRP by increasing the thickness of the dermis and epidermis;A significant increase in dermis thickness was observed in both groups (PRP vs Serum) from 1.27 mm (standard deviation of 0.52) to 1.59 mm (standard deviation of 0.65) post PRP (p equals 0.0576), for example. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate such improvement through visual techniques by VISIA equipment; Through the SHG method, it is expected to find increased collagen in patients treated with PRP.;By the SHG methods, of the 19 patients, there was an expressive but not significant improvement of the collagen fibers increase by SHG microscopy with PRP application and a significant reduction of collagen by the side applied the serum. Regarding the Visia analysis, we observed a decrease in the number of wrinkles in the hemiface treated with PRP (pre 3.9, IQR 2.5 - 8.6, post 3.6, IQR 1.3 - 7.5) but not (pre 4.2, IQR 2.2 - 8.3 and post 5.4, IQR 1.4 - 7.3) (p equals to 0.25). A study recruited 88 women, but only 21 began the study and 19 concluded. | — |
Countries
Brazil
Contacts
Public ContactRebeca Cancela
Faculdade de Ciências Médicas
Outcome results
None listed