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Feasibility Study of the Concomitant Use of Poly-L-Lactic Acid (PLLA) and Hyaluronic Acid

Feasibility analysis of simultaneous application of poly-L-lactic acid (PLLA) and Hyaluronic Acid

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
REBEC
Registry ID
RBR-3mchq3q
Enrollment
Unknown
Registered
2024-09-16
Start date
2024-06-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin Aging

Interventions

The present investigation will be an interventional clinical trial, with two parallel and double-blind arms. A total of 42 anatomical sites from 21 patients, aged between 40 and 80 years, regardless o

Sponsors

Univesrsidade Estadual de Montes Claros
Lead Sponsor
Univesrsidade Estadual de Montes Claros
Collaborator

Eligibility

Age
40 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients diagnosed with facial sagging; age range from 40 to 80 years

Exclusion criteria

Exclusion criteria: History of photosensitivity; keloids; hypertrophic scars and post-inflammatory; hyperpigmentation; pregnancy and lactation; individuals with a local inflammatory skin disorder or active herpes infection at the procedure site; individuals with a history of medical illnesses that contraindicate the procedures; such as intolerance to the components, urticaria to the components; Raynaud's disease and a history of allergic reactions to the components; patients who do not agree to participate in the study

Design outcomes

Primary

MeasureTime frame
Clinical Assessment of Skin Laxity Evaluated by Scale and Cutometer

Secondary

MeasureTime frame
The secondary outcome of this study will address the molecular changes in the tissue expression of collagen 1 and 3. This aspect aims to analyze the molecular mechanisms underlying the changes observed in skin pigmentation, seeking to better understand the biochemical pathways and cellular processes involved in regulating the production of collagen.

Countries

Brazil

Contacts

Public ContactAndre Guimarães

Univesrsidade Estadual de Montes Claros

andreluizguimaraes@gmail.com+55(038)988313705

Outcome results

None listed

Source: REBEC (via WHO ICTRP)