Pneumonia Ventilator-Associated
Conditions
Interventions
This is a randomized controlled clinical trial in critically ill patients. Initially, a pilot study will be conducted with 6 patients (n=6) for standardization of sample collection. After calibration,
E02.594
E05.393.760.560
Sponsors
Faculdade de Odontologia da Universidade de São Paulo
Associação Hospitalar Lenoir Vargas Ferreira
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Critically ill patients admitted to the Intensive Care Unit; undergoing mechanical ventilation; intubated within 24 hours; and aged 18 years or older; both genders
Exclusion criteria
Exclusion criteria: Pregnant patients; edentulous patients; patients with severe traumatic brain injury; postoperative patients expected to be discharged within the first 24 hours; patients diagnosed with COVID; patients intubated for more than 24 hours; patients for whom sample collection is not possible; and patients whose legal representative does not sign the informed consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We infer that patients who remain longer on mechanical ventilation, suffer dysbiosis of the oral microbiome, increasing the risks of infections. | — |
Secondary
| Measure | Time frame |
|---|---|
| The use of aPDT possibly modulates the dysbiotic state reducing the risk of oral and systemic complications related to the presence of microorganisms. | — |
Countries
Brazil
Contacts
Public ContactPaula Sachet
Faculdade de Odontologia da Universidade de São Paulo
Outcome results
None listed