Posture, Motor disorders, Parkinson's disease, Postural Balance
Conditions
Interventions
Acute Transcranial Direct Current Stimulation (tDCS): randomized, sham-controlled, crossover, double-blind design. A single session with anodic tDCS will first be held to determine the intensity that
E02.331.750
Sponsors
Universidade Estadual Paulista (Unesp), Instituto de Biociências (IB)
Universidade Estadual Paulista (Unesp), Instituto de Biociências (IB)
Eligibility
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: Patients should be diagnosed with idiopathic Parkinson's Disease based on the UK Brain Bank criteria; aged between 50 and 85 years; both sexes; make regular use of the Parkinson's disease medication
Exclusion criteria
Exclusion criteria: Patients with score above three in the Hoehn & Yahr scale (H&Y); dementia; change in the Parkinson's Disease medication; musculoskeletal and/or visual impairments that make it impossible to comply the experimental protocol; presence of any uncontrolled disease that could affect peripheral sensory function (e.g., diabetes); risk of receive the stimulation (neural implants, pacemaker, history of seizures and epilepsy)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected the decrease of the onset latency of medial head of the gastrocnemius muscle (MG) (in ms) and the range of CoP (in cm) in patients with PD, calculated by a semiautomatic custom algorithm developed in Matlab environment, after a session with tDCS (mainly with the intensity with 2 mA).;It is expected the decrease of the onset latency of medial head of the gastrocnemius muscle (MG) (in ms) and the range of CoP (in cm) in patients with PD, calculated by a semiautomatic custom algorithm developed in Matlab environment, immediately after the intervention with multiple sessions of tDCS ends and remain for one month after that. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected the decrease in prefrontal cortex activity in the reactive and increases activity in predictive adjustments with passing the trials, verified through a technique that analyzes the hemodynamic response of the brain (in µmol/l)- functional near-infrared spectroscopy (fNIRS) - after a session with tDCS (mainly with the intensity with 2 mA). ;It is expected the decrease in recovery time (in seconds) to the stable position after perturbation, the decrease in prefrontal cortex activity in the reactive and the increase in activity (in µmol/l) in predictive adjustments immediately after the intervention with multiple sessions of tDCS ends and remains for one month after that. The cortical activity is verified through a technique that analyzes the hemodynamic response of the brain - functional near-infrared spectroscopy (fNIRS). | — |
Countries
Brazil
Contacts
Public ContactVictor Beretta
Universidade Estadual Paulista (Unesp), Instituto de Biociências (IB)
Outcome results
None listed