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Effect of heparin to prevent obstruction of the Hickman® catheter

Effectiveness of heparin solution in preventing Hickman® catheter occlusion: clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-3ht499
Enrollment
Unknown
Registered
2017-07-03
Start date
2017-03-22
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

This research will be performed on the Hickman® catheter inserted in the patients submitted to hematopoietic stem cell transplantation. Central venous catheters, hematopoietic stem cell transplantation.

Interventions

The solutions to be compared will be saline solution 0.9% and heparin solution 50 IU / mL. There will be 50 participants for group A and 50 participants for group B. After insertion of the catheter, e
Inspect mechanical causes such as fracture, torsion or traction
ask the patient to inhale and hold the air
And hyperextend the patients neck and ask to place the corresponding hand on the side of the catheter insert in the occipital region. If there is no reflux after the four attempts described above, the
Device

Sponsors

Hospital de Clínicas Universidade Federal do Paraná
Lead Sponsor
Universidade Federal do Paraná
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Being hospitalized in the research unit; Have indication of implantation of Hickman® semi-implantable central venous catheter; Insertion of the Hickman® semi-implantable central venous catheter into the research unit or use of the first Hickman® semi-implantable central venous catheter in the research unit; First hospitalization for transplantation of stem cells in the bone marrow transplantation service in the complex of clinics of the Federal University of Paraná.

Exclusion criteria

Exclusion criteria: Being on anticoagulant by any route of administration; Being in fibrinolytic therapy; Present a history of allergy to heparin components; Bleeding during the period of data collection; Be refractory to platelet transfusion; Have had previous hospitalization in the research unit.

Design outcomes

Primary

MeasureTime frame
This research seeks to identify which blocking solution is most effective in preventing catheter occlusion. There will be two variables of primary outcome: occlusion without reflux or complete occlusion. When opening the catheter pathway, pre-defined intraluminal (reflux) content should be aspirated, with 2 mL for adult and 1 mL for the child. To determine if there was occlusion and the type of occlusion identified, the following analysis will be used: open the clamp and vacuum the contents; Inspect mechanical causes such as fracture, torsion or traction; ask the patient to inhale and hold the air; and hyperextend the patient's neck and ask to place the corresponding hand on the side of the catheter insert in the occipital region. If there is no reflux after the four attempts described above, the catheter must be rinsed without forcing! If, when injecting saline solution 0.9% into the lumen of the catheter, the flow occurs without resistance, the follow-up is closed by occlusion without reflux. Or, if after the four attempts of reflux, the lavage with 0.9% saline is not performed in the lumen of the catheter, that if resistance / pressure is present for the washing, the follow-up of the route by complete occlusion.

Secondary

MeasureTime frame
Secondary outcomes are not expected.

Countries

Brazil

Contacts

Public ContactSandra Silva

Universidade Federal do Paraná

sandra_silvah@yahoo.com.br+55(41)99199.2470

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 16, 2026