Periodontal diseases, smokers
Conditions
Interventions
Groups: Control - twenty patients (womand or man) will receive ultrasonic debridement of the entire mouth in a single session, associated with systemic administration of placebo, for 360 days
Test - twenty patients (womand or man) will receive ultrasonic debridement of the entire mouth in a single session, associated with the systemic administration of 500 mg of resveratrol for 360 days.
R
Dietary supplement
G07.203.300.456
Sponsors
Universidade Paulista
Universidade Paulista
Eligibility
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: Diagnosis of generalized chronic periodontitis with at least 8 teeth with Probing Depth (PD) and Clinical Attachment Level (CAL) equal to or above 5 mm and Bleeding on Probing. Of these 8 teeth chosen, at least two teeth should present PD and CAL equal to or above 7 mm; Presence of at least 20 teeth in the oral cavity;Smoking cigarette for at least 5 years and at least 10 cigarettes per day.
Exclusion criteria
Exclusion criteria: Periodontal treatment in the 6 months prior to the study; Use of medications, such as antibiotics, continuous anti-inflammatories, phenytoin, cyclosporine, in the 6 months prior to the study; Presence of systemic changes or active infectious disease (diabetes, heart disease, hepatitis, etc.); Pregnancy or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected a gain in clinical attachment level and a reduction in probing depthin the group treated with resveratrol compared to the placebo group, by means of clinical measurement OF clinical attachement level and of probing pocket depth using a periodontal probe | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected reduction in the production of pro-inflammatory factors and increase in the production of anti-inflammatory factors in the group treated with resveratrol compared to the placebo group, through the quantification of inflammatory factors, using the immunoenzimatic assay. | — |
Countries
Brazil
Contacts
Public ContactAna Paula Bossolan
Universidade Paulista
Outcome results
None listed