systemic lupus erythematosus, preeclampsia
Conditions
Interventions
All pregnant women diagnosed with systemic lupus erythematosus will perform venous blood collection at 16-18, 24-26, 30-32, 34-36 and 38-40 weeks of gestational age. Serum sFlt-1 / PlGF will be evalua
Other
Sponsors
Universidade do Estado do Rio de Janeiro - Faculdade de Ciências Médicas
Universidade do Estado do Rio de Janeiro - Faculdade de Ciências Médicas
Eligibility
Sex/Gender
Female
Age
16 Years to 45 Years
Inclusion criteria
Inclusion criteria: Pregnant patients diagnosed with systemic lupus erythematosus between will be sequentially enrolled upon prenatal admission.
Exclusion criteria
Exclusion criteria: Patients who do not wish to participate in the study; multiple pregnancies; pregnancies that are interrupted before 20 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected primary outcome 1: Diagnose patients with preeclampsia by measuring blood pressure (BP> or = 140 x 90 mmHg) and 24-hour proteinuria> or = 300 mg / 24 hours. ;Expected primary outcome 2: Diagnose patients with active lupus using the SLEPDAI index. Will be considered active lupus when SLEPDAI is greater than or equal to 4 | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected secondary outcome 1: Diagnose intrauterine growth restriction, based on estimated fetal weight on ultrasound lower than percetile 10 for gestational age. ;Expected secondary outcome 2: Diagnose lupus renal activity, using the SLEPDAI index with at least one positive renal parameter. ;Expected secondary outcome 3: Diagnose fetal death, defined by the absence of fetal heartbeat after 10 weeks, confirmed by ultrasound. | — |
Countries
Brazil
Contacts
Public ContactGuilherme de Jesús
Universidade do Estado do Rio de Janeiro - Faculdade de Ciências Médicas
Outcome results
None listed