Disease by Human immunodeficiency virus (HIV),
Conditions
Interventions
80 volunteers will be recruited who will be randomized into four groups: (1) ART + statin group (n = 20)
(2) ART + placebo group (n = 20)
(3) ART + statin + exercise group (n = 20)
(4) ART + placebo + exercise group (n = 20).
Group (1): this group will use antiretroviral therapy + 10 mg / day of rosuvastatin
Group (2): this group will use antiretroviral therapy + 10 mg flour tablet (placebo)
Group (3): this group will use antiretroviral therapy + 10 mg / day rosuvastatin + physical exercise
Group (4): t
Drug
Other
I02.233.543
HP3.073.433.101
Sponsors
Universidade Federal de Uberlândia
Universidade Federal de Uberlândia
Eligibility
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Being HIV-infected and using antiretroviral therapy for more than a year and being dyslipidemic. Be over 18 years and less than 60. Have health conditions for the practice of the proposed physical exercises. Be sedentary. Have trip availability three times a week to the training location.
Exclusion criteria
Exclusion criteria: Having diagnosis of opportunistic infections in the last two years. Having a diagnosis of liver disease and/or nephropathy and/or neuropathy. Have a history of orthopedic surgery. Have an body mass index> 30 kg / m2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In groups 1, 3 and 4: reduction of pro-inflammatory cytokine concentrations and reduction of cholesterol concentrations. | — |
Secondary
| Measure | Time frame |
|---|---|
| Groups 1, 3, 4: better metabolic profile Groups 3 and 4: improvement of body composition and increase of CD4 + and CD8 + T lymphocytes | — |
Countries
Brazil
Contacts
Public ContactHugo Zanetti
Universidade Federal do Triângulo Mineiro
Outcome results
None listed