Fluorides
Conditions
Interventions
This is a randomized, controlled, double-blind, crossover clinical study involving a total of twenty healthy adult volunteers distributed into four experimental phases of seven days each, separated by
experimental toothpaste containing titanium tetrafluoride alone with one thousand four hundred parts per million of fluoride and pH four point fifty
commercial toothpaste Elmex caries protection containing one thousand four hundred and fifty parts per million of fluoride in the form of amine fluoride with pH four point fifty-five, used as a positi
and fluoride-free placebo toothpaste used as a negative control. During each experimental phase, participants will perform toothbrushing three times daily using approximately one gram of the assigned
Sponsors
Faculdade de Odontologia de Bauru, Universidade de São Paulo
Faculdade de Odontologia de Bauru, Universidade de São Paulo
Eligibility
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: individuals of both sexes aged greater than or equal to eighteen years; residents of the city of Bauru state of São Paulo Brazil with fluoride concentration in the public water supply ranging from zero point seventy seven to zero point eighty seven milligrams of fluoride per liter; presenting good general and oral health characterized by the absence of active or cavitated dental caries and absence of significant gingivitis or periodontitis; presenting stimulated salivary flow greater than or equal to one milliliter per minute; presenting unstimulated salivary flow greater than or equal to zero point twenty five milliliters per minute
Exclusion criteria
Exclusion criteria: presence of systemic disease; pregnancy or breastfeeding; use of orthodontic appliances; professional fluoride application within two months prior to the beginning of the study; smoking; use of medications that may interfere with salivary flow or dental biofilm formation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| to evaluate fluoride retention in solid dental biofilm and in biofilm fluid after the use of different experimental toothpastes; the outcome was verified through collection of solid dental biofilm and biofilm fluid followed by laboratory analysis; variations in fluoride levels among treatments and collection times were observed | — |
Secondary
| Measure | Time frame |
|---|---|
| to evaluate fluoride levels in stimulated saliva after the use of different experimental toothpastes; the outcome was verified through stimulated saliva collection followed by laboratory analysis; variations in fluoride levels among treatments and collection times were observed | — |
Countries
Brazil
Contacts
Public ContactFaculdade de Odontologia de Bauru Universidade de São Paulo
Faculdade de Odontologia de Bauru, Universidade de São Paulo
Outcome results
None listed