Comparison between two types of graft to correct gingival recession: with or without the use of platelet-rich fibrin matrix. Randomized controlled clinical study of divided mouth

The use of subepithelial connective tissue graft, with or without platelet-rich fibrin and leukocyte matrix, in the treatment of multiple bilateral gingival recessions. A randomized controlled split-mouth clinical study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-3db5ny4

Enrollment

Registered

2026-05-25

Start date

2025-11-03

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gingival recession Other periodontal diseases

Interventions

Randomized, double-blind, split-mouth clinical study with a duration of 12 months. The study will follow the guidelines of the Helsinki declaration on human experimentation. Twenty patients with bilat

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years of age; both sexes;full mouth biofilm and bleeding score equal to or less than twenty percent; bilateral Cairo RT1 gingival recessions on three adjacent teeth greater than or equal to 2mm; main complaint esthetics or dentin hypersensitivity

Exclusion criteria

Exclusion criteria: Patients with systemic health problems; contraindication for periodontal surgery; smokers; pregnant or lactating women; previous root covering surgery at the experimental site

Design outcomes

Primary

Measure	Time frame
It’s expected to evaluate the tissue volume change obtained through root coverage in multiple bilateral recessions using subepithelial connective tissue grafting with or without L-PRF matrix; this outcome will be measured through standardized clinical evaluation at 6, 12, and 24 months with photographic, tomographic, and digital records obtained through intraoral scanning; quantitative data will be presented as means and standard deviations; the level of significance adopted will be 5% (p<0.05); intergroup and intragroup differences will be evaluated using the most appropriate parametric or nonparametric tests after analyzing the normality of the data obtained	—

Measure

Time frame

It’s expected to evaluate the tissue volume change obtained through root coverage in multiple bilateral recessions using subepithelial connective tissue grafting with or without L-PRF matrix; this outcome will be measured through standardized clinical evaluation at 6, 12, and 24 months with photographic, tomographic, and digital records obtained through intraoral scanning; quantitative data will be presented as means and standard deviations; the level of significance adopted will be 5% (p<0.05); intergroup and intragroup differences will be evaluated using the most appropriate parametric or nonparametric tests after analyzing the normality of the data obtained

—

Secondary

Measure	Time frame
It's expected to evaluate root coverage percentage, width of the keratinized mucosa band; clinical insertion level; probing depth; quantify cytokine levels in gingival crevicular fluid; dentin hypersensitivity and subjective aesthetic perception comparing the two surgical techniques; quantitative data will be presented with means and standard deviations; the level of significance adopted will be 5% (p<0.05); intergroup and intragroup differences will be evaluated using the most appropriate parametric or nonparametric tests after analyzing the normality of the data obtained	—

Measure

Time frame

It's expected to evaluate root coverage percentage, width of the keratinized mucosa band; clinical insertion level; probing depth; quantify cytokine levels in gingival crevicular fluid; dentin hypersensitivity and subjective aesthetic perception comparing the two surgical techniques; quantitative data will be presented with means and standard deviations; the level of significance adopted will be 5% (p<0.05); intergroup and intragroup differences will be evaluated using the most appropriate parametric or nonparametric tests after analyzing the normality of the data obtained

—

Countries

Contacts

Public ContactArthur Novaes Junior

Faculdade de Odontologia de Ribeirao Preto da Universidade de Sao Paulo

novaesjr@forp.usp.br+55(16)3315-4788

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Jun 11, 2026