Dementia in Alzheimers disease
Conditions
Interventions
An observational case-control study, where it is expected to enroll 128 patients. We will have a group of elderly people with Alzheimers disease (n = 64) and a group of elderly people cognitively pres
Other
Sponsors
Universidade Federal de São Carlos
Universidade Federal de São Carlos
Eligibility
Inclusion criteria
Inclusion criteria: The eligibility criteria are older people aged 54 years old or over, not institutionalized and with the possibility of contacting them by phone or home address. Inclusion criteria are available to participate in the proposed evaluations; present diagnosis of Alzheimer's disease in the mild or moderate phases, according to the Diagnostic and Statistics Manual for Mental Disorders 4th edition (DSM-4) and the Dementia Assessment Score or be preserved cognitively.
Exclusion criteria
Exclusion criteria: The criteria for exclusion are sensorial or function commitments that affect the application of proposed tests and the presence of neurological diseases that interfere in cognition, such as Parkinson's disease, stroke, multiple sclerosis, Huntington's disease, epilepsy, and brain trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EXPECTED OUTCOME 1:The main outcome is body composition. For analysis of body composition, the Dual Energy X-Ray Absorptiometry (DEXA) device (Discovery A, Hologic brand) will be used, which measured the body lean mass, body fat mass, and body bone mass. The exam will be realized according to the manufacturer's recommendations. The volunteer will be positioned in the supine position and must remain motionless during the exam. Lean mass measurement includes body water, internal organs, and muscle mass. Three measures will be taken: densitometry of the body mass in the whole body, densitometry of the lumbar spine and densitometry of the left hip. It is expected that the cognitively preserved group has a greater amount of lean mass and bone mass and less fat mass when compared to the group of elderly people with Alzheimer's disease. In addition, it is expected to find a correlation between low bone mineral density, sarcopenia and Alzheimer's disease, with the decline in bone mass and muscle strength being more intense as the severity of AD staging is also greater. | — |
Secondary
| Measure | Time frame |
|---|---|
| EXPECTED OUTCOME 2:The secondary outcome consists of collecting data to characterize the sample, which includes clinical and anthropometric measurements (gender, age, education, ethnicity, marital status, recent fracture, number of medications, number of falls, smoking, drinking, body mass index, waist-to-hip ratio, number of medications in continuous use, level of physical activity), cognitive function (MMSE and CDR), muscle strength (5TSTS), sarcopenia (SARC-F), depressive symptoms (GDS) and level of functionality (Pfeffer's Functional Activities Questionnaire). It is expected that, regardless of the level of physical activity, older people with Alzheimer's disease present higher levels of sarcopenia, less muscle strength, more depressive symptoms and functional deficits. | — |
Countries
Brazil
Contacts
Public ContactNatália de Castro Cezar
Universidade Federal de São Carlos
Outcome results
None listed