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Use of Simvastatin Gel for the treatment of Peri-implantitis

Clinical and radiographic evaluation of the efficacy of Simvastatin in Regenerative Therapy for Peri-implantitis: a controlled and randomized clinical trial

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
REBEC
Registry ID
RBR-3bqywp7
Enrollment
Unknown
Registered
2024-03-07
Start date
2021-09-21
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

periimplantitis

Interventions

This is a two-arm, double-blind, randomized controlled clinical study. A total of 30 people who meet the eligibility criteria will be randomly allocated to one or another intervention group using a co

Sponsors

Universidade Estadual Paulista, Faculdade de Odontologia de Araraquara, FOAR-UNESP
Lead Sponsor
Universidade Estadual Paulista, Faculdade de Odontologia de Araraquara, FOAR-UNESP
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Greater than or equal to eighteen years of age; greater than or equal to three radiographic bone loss ; greater than or equal to six millimeters of probing pocket depth with bleeding on probing; less than or equal to twenty percent of plaque index; less than or equal to twenty percent of gingival index ; formal consent to participate in the research

Exclusion criteria

Exclusion criteria: Presence of uncontrolled systemic alteration; use of medications six months prior to the study that may influence the response to treatment; pregnant and lactating women, performing peri-implant treatment including subgingival instrumentation in the six weeks prior to the study; implants with mobility; oral pathology; history of allergy to any component of the study

Design outcomes

Primary

MeasureTime frame
It is expected to find a gain in radiographic bone filling of at least 1mm through linear measurements using the implant platform and the bottom of the defect as reference points using the ImageJ program.

Secondary

MeasureTime frame
It is expected to find a reduction on probing pocket depth of at least 1mm through clinical measurements using a periodontal probe from gingival margin to the bottom of the implant pocket as reference points.

Countries

Brazil

Contacts

Public ContactJavier Vivanco

Universidade Estadual Paulista, Faculdade de Odontologia de Araraquara, FOAR-UNESP

javier.vipu@gmail.com+55(16)3301-6359

Outcome results

None listed

Source: REBEC (via WHO ICTRP)