Dentin Sensitivity back pain
Conditions
Interventions
This study consists of a series of controlled, randomized, triple-blind, split-mouth interventional clinical trials linked to a clinical umbrella project. Each trial will be conducted independently us
(2) membrane containing glutaraldehyde
and (3) membrane containing the association of ibuprofen and glutaraldehyde. In each trial, the experimental intervention will be compared with a placebo membrane applied to the corresponding contrala
Sponsors
Colegiado de Odontologia da Universidade Estadual do Oeste do Paraná (UNIOESTE)
Universidade Estadual do Oeste do Paraná (UNIOESTE)
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Volunteers will be selected who are at least 18 years old; in good general and oral health; who have at least two teeth with a clinical diagnosis of dentin hypersensitivity. Eligible teeth must have dentin exposure associated with non-carious cervical lesions, such as gingival recession, abrasion, erosion, or abfraction, and a painful response to an evaporative stimulus (air jet), with a minimum intensity of 3 on the Visual Analog Scale
Exclusion criteria
Exclusion criteria: Individuals who present active carious lesions on the teeth to be evaluated; extensive or defective restorations in the cervical region of the selected teeth; cracks or dental fractures in the area of interest; or uncontrolled periodontal disease will be excluded. Participants who have undergone treatment for dentin hypersensitivity or used desensitizing agents in the last three months will also be excluded, as well as those who are continuously using analgesics, anti-inflammatories, or medications that may interfere with pain perception. Individuals who have recently undergone dental treatment in the evaluated region; users of orthodontic appliances; pregnant or breastfeeding women; and those with a history of allergy to any component of the formulations used in the study will also not be considered eligible to participate in the research
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of dentin hypersensitivity in individuals with a clinical diagnosis of the condition, assessed using a validated pain scale (Visual Analogue Scale – VAS or numerical rating scale), after standardized evaporative stimulus, across different follow-up time points. | — |
Secondary
| Measure | Time frame |
|---|---|
| Intensity of dentin hypersensitivity at each assessment time point (7, 14, 30, 60, 90, 120, and 180 days), according to the desensitizing strategy employed. Temporal evolution of dentin hypersensitivity over the 6-month follow-up period. Proportion of participants showing a clinically significant reduction in pain (e.g., =30% or =50% on the VAS) in each experimental group. Occurrence of adverse events, local or systemic, related to the use of electrospun polymeric membranes and the incorporated desensitizing agents. Duration of the desensitizing effect, defined as the time required for sustained reduction or return of dentin sensitivity to baseline values, when applicable. | — |
Countries
BR
Contacts
Public ContactVeridiana Camilotti
Universidade Estadual do Oeste do Paraná (UNIOESTE)
Outcome results
None listed