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Effects of Resistance Training with Blood Flow Restriction on muscle strength, mass, and quality of life of Cirrhotic patients

Resistance Training with Blood Flow Restriction in Cirrhotic patients: effects on strength, muscle mass, functionality and quality of life

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-395mfw
Enrollment
Unknown
Registered
2018-09-25
Start date
2018-09-17
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Liver Cirrhosis, muscle strength, hypertrophy

Interventions

30 participants will be randomly distributed in a counterbalanced way between two groups: 1) 15 participants (n = 15) to the resistance training with blood-flow restriction group(BFR-RT)
and 2) 15 participants (n = 15) to the control group (CTRL). Assessments will be carried out in two different time points: before the training intervention (0W) and after twelve weeks (12W). The follo
Other
E02.760.169.063.500.387

Sponsors

Centro de Ciências Biológicas e da Saúde da Universidade Federal de São Carlos
Lead Sponsor
Cleiton Augusto Libardi
Collaborator

Eligibility

Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Liver cirrhosis confirmed through histopathological assessment, hepatic elastography, or clinical, radiological or endoscopic criteria

Exclusion criteria

Exclusion criteria: Active alcohol intake in the previous 6 month; MELD score above 15; Child-Pugh class C; decompensated chronic diseases; diabetes mellitus; hepatocellular carcinoma or other neoplasms; previous liver transplantation; severe ascites; persistent hepatic encephalopathy; clotting disorders characterized by INR superior to 1.5 or platelets inferior to 75,000; medical contraindication exercise

Design outcomes

Primary

MeasureTime frame
Significant hypertrophy for the vastus lateralis muscle after 12 weeks of resistance training, assessed through ultrasound imaging Significant increase in knee extensors muscle strength after 12 weeks of resistance training, assessed though 1 repetition maximum test Significant increases in pennation angle and fascicle length after 12 weeks of resistance training, assessed through ultrasound imaging Significant increase in functionality, assessed through the timed-up-and-go, 6-minute walk and 30-second rising and sitting tests—

Secondary

MeasureTime frame
Maintenance of the liver cirrhosis scores, with no alterations in MELD and Child-Pugh scores after 12 weeks of resistance training—

Countries

Brazil

Contacts

Public ContactCleiton Libardi

Universidade Federal de São Carlos

c.libardi@ufscar.br55(16)3351-8294

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 18, 2026