Signs and Symptoms, Digestive Stress, Psychological
Conditions
Interventions
This is a randomized, double-blind, controlled study. Probiotic group: Capsules containing a total of 6 billion colony-forming units (CFU), including Lactiplantibacillus plantarum ID LP01-ID 1171, Lac
Sponsors
Universidade Federal de São Paulo
Universidade Federal de São Paulo
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Undergraduate student ; self-reported stress; presence of gastrointestinal symptoms.
Exclusion criteria
Exclusion criteria: Current treatment for gastrointestinal symptoms (medications or probiotic supplements) or for anxiety/depression (antidepressants, anxiolytics, or antibiotics) within the past three months; any physical limitation or disability.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probiotic supplementation reduced gastrointestinal symptoms and Depression, Anxiety and Stress Scale-21 (DASS-21) scores. | — |
Secondary
| Measure | Time frame |
|---|---|
| Probiotic supplementation increased salivary Brain-Derived Neurotrophic Factor (BDNF) levels. ;Probiotic treatment positively modulated autonomic function, with significant effects on the low-frequency (LF), high-frequency (HF), and LF/HF ratio. ;Probiotics increased serum IL-10 levels and decreased IL-12 levels. | — |
Countries
BR
Contacts
Public ContactLivia Souza
Universidade Federal de São Paulo
Outcome results
None listed