Nasal polyp. Nasal Polyps. Chronic sinusitis. Sinusitis
Conditions
Interventions
Participation in the study will be offered orally to all thirty eligible patients who are referred to the Rhinology Outpatient Clinic.
CONTROL GROUP: 15 subjects
At admission, all patients should b
Drug
E02.319
Sponsors
Hospital das Clínicas da UNICAMP/Faculdade de Ciências Médicas.
Hospital das Clínicas da UNICAMP/Faculdade de Ciências Médicas.
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patient with chronic rhinosinusitis with bilateral nasal polyps; with or without allergy; with or without asthma; from any gender; older than 18 years old.
Exclusion criteria
Exclusion criteria: Patients younger than 18 years; women of childbearing or non-sterilized age; current or previous use of isotretinoin; history of nasal surgery for less than 5 years; non-controlled diabetic patients or poorly controlled hepatopathies and nephropathies; patients with cystic fibrosis or mucociliary diseases; presence of larger nasal tumors or malformations; cocaine or other inhaled drug user; patients with primary or secondary immunodeficiencies, coagulopathies, blood dysplasias, systemic or granulomatous vasculitis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of nasal polyps volume, evaluated by nasofibroscopy, CT scan, and quality of life questionnaire, depicted as a reduction of at least 50% of polyps volume to nasofibroscopy and a reduction of 10% of the scores hailed from CT scan and quality of life questionnaire. Data collected 3 months before the intervention and 3 months after the intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| Decreased Th2 inflammatory cytokines present in the nasal polyp, measured by multiplex assays, present in homogenates of biopsy fragments, performed 3 months before the intervention and hailed months after the intervention. | — |
Countries
Brazil
Contacts
Public ContactMarcelo Antonio
Departamento de Oftalmologia e Otorrinolaringologia, ambulatório de Rinologia
Outcome results
None listed