Constipation Parkinson Disease
Conditions
Interventions
This submission refers to the second phase of the study. A clinical study involving patients with Parkinson&apos
s disease (PD) was conducted in two phases. In the first part of the study, a cross-sectional observational study was conducted to identify patients with symptoms of constipation. Patients with PD and
Sponsors
Hospital Ophir Loyola
Universidade Federal do Pará
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Parkinson Disease patients; constipation symptoms according to the bristol scale types 1 and 2 and diagnosis of chronic constipation according to the Rome III criteria; age over 18 years old; both sexes, agree to participate in data collection and sign the free and informed consent form (TCLE)
Exclusion criteria
Exclusion criteria: Patients diagnosed with dementia associated with Parkinsoon Disease, according to the criteria of the movement disorders society task force; history of other neurological diseases, with associated and diagnosed psychiatric illnesses; use of oral laxative medicatios, enemas and laxative suppositories during the study; use of antibiotics one month before the initial assessment; diagnosis or history of inflammatory and neoplastic gastrointestinal diseases
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: To evaluate the number of weekly bowel movements after a nutritional intervention based on the principles of the Mediterranean diet in individuals with Parkinson's disease and constipation. ;Observed outcome 1: An increase in weekly bowel movements was observed after the intervention compared with the assessments performed before the follow-up period.;Expected outcome 2 : To evaluate gastrointestinal symptoms related to constipation after a nutritional intervention based on the principles of the Mediterranean diet in individuals with Parkinson's disease.;Observed outcome 2:Improvement in gastrointestinal symptoms related to constipation was observed throughout the follow-up period, accompanying the increase in bowel movement frequency and the normalization of stool consistency over the six-month follow-up | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 3: To evaluate adherence to the Mediterranean diet using the Food Frequency Questionnaire and the Mediterranean Diet Adherence Screener (MEDAS), as well as the evolution of gastrointestinal symptoms related to constipation.;Observed outcome 3: Improved adherence to the Mediterranean diet was observed throughout the follow-up period, as assessed using the Food Frequency Questionnaire and the Mediterranean Diet Adherence Screener (MEDAS).;Expected outcome 4: To evaluate the number of weekly bowel movements and improvement in constipation using the Bristol Stool Form Scale after a Mediterranean diet-based nutritional intervention in individuals with Parkinson's disease.;Observed outcome 4:Improvement in stool consistency, assessed by the Bristol Stool Form Scale, was observed during follow-up. No statistically significant differences were found between the MedDiet and WaitList groups after three months (ß=0.10; 95% CI: -0.4 to 0.6; p=0.732). However, longitudinal analyses demonstrated progressive normalization of stool consistency over the six-month follow-up period. | — |
Countries
BR
Contacts
Public ContactRaissa Fernandez
Universidade Federal do Pará
Outcome results
None listed