Female pattern hair loss
Conditions
Interventions
This is a prospective study (randomized clinical trial), in which clinical, dermoscopic and histopathological evaluation of the scalp of patients diagnosed with female pattern hair loss was carried ou
Sponsors
Hospital das Clínicas da Universidade Federal do Paraná
Hospital das Clínicas da Universidade Federal do Paraná
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age greater than 18 years old and less than 65 years old; clinical and dermoscopic diagnosis of female pattern alopecia under regular treatment for at least 12 months with the same dosage of medications, and limited response to treatment
Exclusion criteria
Exclusion criteria: Clinical, dermoscopic or histological signs of scarring alopecia; non-compliance with any study procedures; triggers for telogen effluvium in the last three months before inclusion in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: It is expected to find an increase in the number of total follicles and a reduction in telogen follicles after the procedure in the microinfusion group with minoxidil compared to the group with saline solution (control), verified by histopathological analysis, based on the counting and identification of follicles, and use of the Mann-Whitney statistical test to compare the two groups;Outcome found 1: No significant difference was observed in the various histological parameters between the two groups. The analysis was carried out by comparing the pre- and post-procedure variation of parameters in the two groups, applying the Mann-Whitney test. In the Minoxidil treatment group, there was a significant reduction in terminal follicles (p=0.032) after the procedure. Therefore, no benefit was observed from the use of minoxidil compared to the use of saline solution for scalp microinfusion | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 1: It is expected to find a reduction in blood pressure in the microinfusion group with minoxidil comparing the pre and post procedure moments, with no variation in the saline solution group (control), based on the Wilcoxon statistical test;Outcome found 1: Comparing pre- and post-procedure values, a significant reduction was seen in diastolic blood pressure after the procedure in the minoxidil group. In the control group, there was a significant increase in systolic blood pressure after the procedure, verified by statistical analysis using the Wilcoxon test | — |
Countries
Brazil
Contacts
Public ContactFlávia Basilio
Hospital das Clínicas da Universidade Federal do Paraná
Outcome results
None listed