Gonarthrosis (knee osteoarthritis)
Conditions
Interventions
All patients will be submitted to viscosupplementation with 80 mg of hyaluronic acid and 160 mg of sorbitol (Synolis-VA® 4.0 ml) single dose intra-articular injection
And all patients will undergo radiography of the knee AP and Profile with load once only on the same date of viscosupplementation. All patients will be evaluated by the WOMAC, SF-12 and EVA questionna
Drug
Radiation
E02.718.875
Sponsors
Universidade Federal de São Paulo
Ortocity
Eligibility
Age
45 Years to 120 Years
Inclusion criteria
Inclusion criteria: Osteoarthritis grade 1 to 4 Kellgren and Lawrence. Magnetic resonance Imaging of the knee 1.5 T performed up to 3 months before viscosupplementation. Failure of conservative treatment for knee osteoarthrosis: pain > 5 on Visual Analogue Scale on walk after 30 days of performed standardized physiotherapy 10 sessions and simple analgesia.
Exclusion criteria
Exclusion criteria: Magnetic resonance imaging with insufficient protocol or inadequate technique. Radiographies with inadequate technique. Non-inclusion criteria: Systemic inflammatory disease; Diagnosis of other orthopedic conditions in the affected lower limb; Viscossupplementation or other infiltration in the affected knee performed up to 12 months prior to the study; Corticosteroids in the last 6 months; History of previous allergy to Hyaluronic acid or Sorbitol; Pregnant;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main outcome is the improvement in physical function after viscosupplementation, assessed by the Western Ontario and McMaster Universities Osteoarthritis Index questionnaire (WOMAC), compared immediately before, two weeks, three months and six months after.;SF-12v2® Health Survey Standard, physical and mental health scale, performed immediately before, two weeks, three months and six months after viscosupplementation.;Pain intensity assessed by visual analog scale (VAS), performed immediately before, two weeks, three months and six months after viscosupplementation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Semiquantitative score for knee osteoarthritis according to the criteria defined by the MRI Osteoarthritis Knee Score (MOAKS) before viscosupplementation;Angle of the femorotibial axis on radiography;Kellgren Lawrence Classification on radiography;Volume of Articular effusion immediately before viscosupplementation;Body mass index (BMI);Previous knee surgery | — |
Countries
Brazil
Contacts
Public ContactGustavo Pinto
Universidade Federal de São Paulo
Outcome results
None listed