Neuromuscular block
Conditions
Interventions
Intervention group: the tetanus stimulus with 50 Hz will be used in 20 patients aged 60 to 80 years undergoing elective surgery under general anesthesia to decrease the stabilization time of the muscl
Device
Sponsors
Hospital Universitário Gaffrée e Guinle- Universidade Federal do Estado do Rio de Janeiro
Hospital Universitário Gaffrée e Guinle- Universidade Federal do Estado do Rio de Janeiro
Eligibility
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: both genders;age 60 to 80 years;physical state American Society of Anesthesiologists (ASA) I to III;body mass index 18.5 to 29;surgeries lasting 60 minutes or more;patients who will undergo surgery with a single dose of neuromuscular blocking drug
Exclusion criteria
Exclusion criteria: refusal to participate in the study;presence of neuromuscular diseases, renal or hepatic dysfunction;history of difficult airway predictors;use of furosemide, aminoglycosides, aminophylline, azathioprine, cyclophosphamide, anti-inflammatories and magnesium;allergy to the drugs used in the study;intercurrences in the perioperative that need alteration in the project;participants who already participate in other clinical studies within the study hospital
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the interference of the tetanus stimulus used to stabilize the neuromuscular monitor signal in the time of recovery from the neuromuscular block verified by the relationship between the fourth stimulus and the neuromuscular monitor on the first stimulus (T4/T1), that translate muscle contraction and the degree of reversal of neuromuscular block | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the initial and final height of the first stimuli (T1), the time to obtain stability of the height of T1 and the adjustments of the neuromuscular monitor ;Evaluate the recovery time of the train-of-four (TOF) 0.9 normalized and the recovery time of the train-of-four stimuli (TOF) 1.0 normalized;Evaluate the safety in extubating the patient ensuring recovery from neuromuscular block, translated in the train-of-four(TOF) above 0.9 to the monitor | — |
Countries
Brazil
Contacts
Public ContactAngela ;Ismar Ribeiro;Cavalcanti
Angela Henrique Silva Ribeiro;Hospital Universitário Gaffrée e Guinle- Universidade Federal do Estado do Rio de Janeiro
Outcome results
None listed