Kidney Diseases
Conditions
Interventions
This is a randomized, triple-blind clinical trial. Adult patients (a minimum of approximately 1600) of both biological sexes, aged 18 years or older, with chronic kidney disease undergoing conservativ
strength training (subdivided into strength training-conservative, strength training-hemodialysis, strength training-peritoneal dialysis, strength training-transplant recipients, with approximately 10
aerobic training (subdivided into aerobic training-conservative, aerobic training-hemodialysis, aerobic training-peritoneal dialysis, aerobic training-transplant recipients, with approximately 100 par
and combined training (subdivided into combined training-conservative, combined training-hemodialysis, combined training-peritoneal dialysis, combined training-transplant recipients, with approximatel
E02.760.169.063.500.387.875
Sponsors
Strictu Sensu em Educação Fìsica
Universidade Católica de Brasília
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Person diagnosed with chronic kidney disease and who have persistent albuminuria (>300mg/g) following the KDIGO - Kidney Disease: Improving Global Outcomes guidelines; metabolic syndrome {i.e., type 2 diabetes mellitus, arterial hypertension (blood pressure>180/100mmHg), overweight or obesity, and dyslipidemia}; do not have complications arising from preexisting clinical metabolic diseases (i.e., diabetic coma, ketoacidosis, hyperosmolarity, and/or uncontrolled diabetes), evaluated by a nephrologist; absence of neurodegenerative, osteomyoarticular diseases, lupus erythematosus, or congenital kidney disease; do not have apparent cardiovascular complications, such as heart failure, severe arrhythmia, angina, or cerebrovascular disease; do not have comorbidities that limit performance in physical tests or training; have not been engaged in physical exercise programs for at least six months prior to the start of the experimental protocol; have no smoking or alcohol consumption behavior; D-dimer values ??within normal values ??(220-500 ng/mL); patients of both sexes; and over 18 years of age
Exclusion criteria
Exclusion criteria: Practice physical exercise regularly; have suffered a stroke in the last 6 months and/or have autoimmune diseases; unstable cardiac dysfunctions, such as: non-stabilized coronary disease, aneurysm at risk of rupture, uncontrolled arrhythmia, uncontrolled hypertension (SystolicBloodPressure> 190 mmHg and/or DiastolicBloodPressure> 100 mmHg); infarction in the last 3 months; infectious conditions, Hemoglobin lower than 8 in the last monthly routine hemodialysis exam; myoarticular pain; fever; oxygen saturation (SpO2) at rest less than 94%; restriction of clinical staff will be excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to verify a reduction in the concentrations of uremic toxins in the body, measured by serum biochemical markers, after specific interventions such as physical training in patients with chronic kidney disease, over a follow-up period of at least 6 months and up to 10 years | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to verify an improvement in the quality of life and psychosocial aspects of patients, such as emotional well-being, stress levels, depression, and social functioning, measured by standardized and validated questionnaires, after specific interventions, such as physical training, in patients with chronic kidney disease, over a follow-up period of at least 6 months and up to 10 years;It is expected to verify a change in body composition including alterations in lean mass, fat mass, and fat distribution, assessed by Dual-Energy X-ray Absorptiometry, Pollock 7-site skinfold protocol, bioimpedance, and Body Mass Index, after specific interventions, such as physical training, in patients with chronic kidney disease, over a follow-up period of at least 6 months and up to 10 years;It is expected to verify an improvement in cardiopulmonary capacity, assessed by anaerobic threshold, respiratory muscle strength analysis, and spirometry, after specific interventions, such as physical training, in patients with chronic kidney disease, over a follow-up period of at least 6 months and up to 10 years;It is expected to verify an improviment in autonomic cardiac function, assessed by autonomic cardiovascular regulation during deep breathing, Valsalva maneuver, heart rate variability, and blood pressure variability, after specific interventions such as physical training in patients with chronic kidney disease, over a follow-up period of at least 6 months and up to 10 years;It is expected to verify an improviment in the nutritional profile, assessed by 24-hour dietary recall, food frequency questionnaire, and indicators of macro and micronutrient intake, after specific interventions such as physical training in patients with chronic kidney disease, over a follow-up period of at least 6 months and up to 10 years;It is expected to verify an reduction in the concentrations of uremic toxins, such as indoxyl sulfate, p-Cresyl sulfate, hippuric acid, and trimethylamine N-oxide, | — |
Countries
Brazil
Contacts
Public ContactLysleine Deus
Universidade Católica de Brasília
Outcome results
None listed