Oral candidiasis associated with the use of removable dental prosthesis.
Conditions
Interventions
Participants with a confirmed diagnosis of prosthetic stomatitis were divided into two groups: 1) Experimental: 18 subjects received a treatment kit containing a sealed vial (450 mL) of mouthwash, a m
2) Control: 18 subjects received a treatment kit, which contained a sealed vial (450 mL) of mouthwash, one dose cup (10 mL), one spray (150 mL) containing nystatin applied under the same conditions ap
Drug
Sponsors
Universidade Federal da Paraíba
Universidade Federal da Paraíba
Eligibility
Age
No minimum to 70 Months
Inclusion criteria
Inclusion criteria: Individuals aged 40 to 70 years with oral candidiasis and who wore removable dentures.
Exclusion criteria
Exclusion criteria: Individuals who had undergone topical and/or systemic antimicrobial treatment or were sensitive to C. zeylanicum EO or nystatin were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Presentation of the expected outcome: improvement of clinical aspects (coloration, texture, presence of pseudomembrane and edema) of the palatal mucosa, verified from clinical examination by visual inspection and palpation before and after the study. Data collected before and after 15 days of use of the experimental and control products. According to the parameter defined for the sample calculation, a cure rate of 80% is expected.;Presentation of observed outcome: From the results obtained and statistical analysis performed, there was a significant clinical improvement (p = 0.0139, Wilcoxon test), with a 55.6% cure rate. | — |
Secondary
| Measure | Time frame |
|---|---|
| Presentation of expected secondary outcome: decrease in the number of colony forming units of Candida spp., Verified from mycological examination of the affected mucosa, observed before and after use of the experimental product.;Presentation of the secondary endpoint observed: No change in the number of colony forming units of Candida spp., Verified from mycological examination of the affected mucosa, observed before and after use of the experimental product. | — |
Countries
Brazil
Contacts
Public ContactRicardo;Ricardo Castro;Castro
Universidade Federal da Paraíba;Universidade Federal da Paraíba
Outcome results
None listed