Myocardial Ischemia
Conditions
Interventions
This is a unicentric, cross-sectional study to be developed at the Complexo Hospital de Clínicas of the Federal University of Paraná (CHC-UFPR). 45 patients, between februrary 2023 and february 2024,
with a ratio of positive and negative cases of 1:4) will undergo a complete transthoracic echocardiogram and then a pharmacological stress test with dobutamine/atropine (cineloops will be acquired at
with low doses of dobutamine - 5 to 20 mcg.kg/min -, high doses of dobutamine - 20 to 40 mcg/kg/min -, and recovery
infusion of atropine 0.25 mg will be allowed during the high dose phase if the patient does not reach submaximal heart rate). The images will be archived and post-processing will be performed using sp
E01.370.350.130.750.228
Sponsors
Complexo Hospital de Clínicas da Universidade Federal do Paraná
Complexo Hospital de Clínicas da Universidade Federal do Paraná
Eligibility
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients undergoing stress echocardiography for assessing Myocardial Ischemia due to chest pain or dyspnea; both genders; age between 18-80 years old; Left ventricular ejection fraction greater than 50%
Exclusion criteria
Exclusion criteria: Patient refusal; limitations for assessing left ventricular function by echocardiography; left ventricular ejection fraction less then 50%; prosthetic valves or valve disease graded as moderate or severe; atrial fibrillation; allergy or abnormal reaction to dobutamine; exclusion criteria for the use of atropine during dobutamine stress echocardiography are glaucoma and obstructive prostatic disease, in which case only dobutamine is used as a pharmacological stressor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the accuracy of left atrial longitudinal strain for detection of myocardial ischemia;Evaluate the accuracy of left atrial longitudinal strain for detection of myocardial ischemia | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate the distribution of left atrial longitudinal strain values ??at rest and after stress (pharmacological with dobutamine/atropine) in patients of low, moderate and high cardiovascular risk.;Evaluate the correlation of left atrial longitudinal strain with the pretest probability of coronary artery disease;Evaluate the distribution of left atrial longitudinal strain values ??at rest and after stress (pharmacological with dobutamine/atropine) in patients of low, moderate and high cardiovascular risk.;Evaluate the correlation of left atrial longitudinal strain with the pretest probability of coronary artery disease | — |
Countries
Brazil
Contacts
Public ContactEduardo Bonotto
Complexo Hospital de Clínicas da Universidade Federal do Paraná
Outcome results
None listed