Primary pulmonary hypertension
Conditions
Interventions
Inspiratory muscle training with 50% or 2% of maximal inspiratory muscle strength in patients with pulmonary arterial hypertension. The training will be performed seven days a week, two series of thir
Other
E01.370.600.425
E02.779.483.875
Sponsors
Irmandade Santa Casa de Misericórdia de Porto Alegre
Universidade Federal do Rio Grande do Sul
Universidade Federal de Ciências da Saúde de Porto Alegre
Eligibility
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Target sample:32 patients. Patients with pulmonary hypertension confirmed by right heart catheterization; the patient must be over 18 years; patients belonging to group I of pulmonary hypertension; patient in functional class II or III of world health organization; patients with specific drug treatment for pulmonary hypertension stable for at least three months; patients willing to complete the training; patients with inspiratory muscle strength less than 70% predicted.
Exclusion criteria
Exclusion criteria: Patients using oxygen; patients with significant musculoskeletal disorders, intermittent pain; cognitive or neurological deterioration; patients with psychiatric-psychological disorders that may interfere in the understanding of the protocol; patients with a history of moderate or severe chronic lung disease; patients with hemodynamic instability; unstable angina or uncontrolled cardiac arrhythmia; patients who were hospitalized in the last three months; patients who participated in supervised exercise programs in the past three months; patients with inspiratory muscle strength more than 70% predicted.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement in exercise endurance capacity. It is assessed by the endurance constant test by cycle ergometer. The result will be above 270 seconds of the baseline time of the exercise tolerance with same load. | — |
Secondary
| Measure | Time frame |
|---|---|
| Equilibrium in the sympathetic and parasympathetic modulation balance measured by spectral analysis obtained from the ECG. There are no absolute numbers for such an assessment, but a balance between the sympathetic and parasympathetic modulations (50% each one).;Increase in muscle strength measured by manuvacuometer with result an increase greater than 70% of the value predicted.;Improvement of functional capacity measured by the six-minute walk test, with an increase over 32 meters in the walk distance.;Improvement of physical and mental summarized domains measured by the questionnaire of quality of life SF36 from baseline data with an increase at least 3 points in each domain (physical and mental).;Improvement in endothelial function measured by brachial artery ultrasound with results proving an increase of at least 8% of the vessel elasticity. | — |
Countries
Brazil
Contacts
Public ContactFabricio;Gabriela da Fontoura;Roncato
Universidade Federal do Rio Grande do Sul;Universidade Federal de Ciências da Saúde de Porto Alegre
Outcome results
None listed