Rejuvenation Skin aging
Conditions
Interventions
This is a three-arm, randomized, controlled, single-blind clinical trial. The study will include a total number of sixty-six participants, equally divided into three groups, with twenty-two participan
Sponsors
Universidade de São Paulo
Universidade de São Paulo
Eligibility
Age
45 Years to 72 Years
Inclusion criteria
Inclusion criteria: participants of both genders aged between forty-five and seventy-two years; individuals classified as types one, two, and three on the fitzpatrick skin color scale; individuals classified as grades three and four on the glogau global aging scale; individuals in good general health status; participants who demonstrate commitment to using cosmeceuticals and sunscreen daily as directed; individuals who voluntarily sign the informed consent form
Exclusion criteria
Exclusion criteria: individuals who work outdoors or perform outdoor activities and cannot temporarily withdraw from these activities; participants who are currently using isotretinoin or who have discontinued its use less than six months ago; individuals with the presence of systemic diseases; participants allergic to any component of the cosmeceuticals, sunscreen, or trichloroacetic acid; individuals with a history of atrophic or hypertrophic scarring, or keloid formation; pregnant, recently postpartum, or lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the variation in skin texture, spots, and porosity, verified by the three-dimensional topography method using the VISIA equipment, through which we will observe the numerical reduction of wrinkle and surface spot indices comparing baseline data with results obtained at ninety days. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the clinical efficacy in facial rejuvenation and wrinkle depth reduction, verified by the method of standardized photographic analysis with evaluation by blinded specialists, where we will observe a reduction of at least one grade in the referred scale in fifty percent of the participants in each intervention group after the ninety-day period, as well as to measure the level of clinical discomfort verified by the Visual Analogue Scale for pain, where we will observe which intervention presents a higher average numerical score reported by participants immediately after the procedure.;To evaluate the participants' perception of aesthetic improvement, verified by a standardized satisfaction questionnaire method, where we will observe an increase in the personal satisfaction index with facial appearance after ninety days compared to the beginning of the study. | — |
Countries
BR
Contacts
Public ContactCristina Araujo
Universidade de São Paulo
Outcome results
None listed