Use of Light Therapy as support for Gum Treatment in patients with Periodontitis

Effect of Photodynamic Therapy as an adjunct to Non-Surgical Periodontal Treatment in patients with Periodontitis randomized controlled clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-328f225

Enrollment

Registered

2026-04-09

Start date

2026-05-01

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aggressive Periodontitis Periodontitis

Interventions

This is a randomized controlled clinical trial with two parallel arms and double blinding. A total of 60 participants diagnosed with stage III and IV periodontitis will be randomly allocated into two

Eligibility

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: individuals of both sexes; age 18 years or older; diagnosis of stage III or IV periodontitis; no periodontal treatment within the last three months; no antibiotic therapy within the last three months

Exclusion criteria

Exclusion criteria: smoking; presence of uncontrolled systemic diseases; uncontrolled diabetes mellitus; pregnancy or lactation; malignant diseases; oncologic treatment; use of orthodontic appliances; allergy to methylene blue; age over 60 years

Design outcomes

Primary

Measure	Time frame
Improvement in clinical periodontal parameters including clinical attachment level, probing depth, bleeding on probing, and dental biofilm index will be evaluated through clinical periodontal examination using a calibrated periodontal probe at six sites per tooth, assessed at baseline before the intervention and at 90 days after non-surgical periodontal treatment with or without antimicrobial photodynamic therapy	—

Measure

Time frame

Improvement in clinical periodontal parameters including clinical attachment level, probing depth, bleeding on probing, and dental biofilm index will be evaluated through clinical periodontal examination using a calibrated periodontal probe at six sites per tooth, assessed at baseline before the intervention and at 90 days after non-surgical periodontal treatment with or without antimicrobial photodynamic therapy

—

Secondary

Measure	Time frame
Changes in immunoinflammatory marker levels including interleukin 1 beta, interleukin 6, interleukin 17, and tumor necrosis factor alpha in gingival crevicular fluid will be evaluated using enzyme linked immunosorbent assay, based on samples collected with absorbent paper points inserted into the periodontal pocket for 30 seconds, assessed at baseline before the intervention and at 90 days after non-surgical periodontal treatment with or without antimicrobial photodynamic therapy	—

Measure

Time frame

Changes in immunoinflammatory marker levels including interleukin 1 beta, interleukin 6, interleukin 17, and tumor necrosis factor alpha in gingival crevicular fluid will be evaluated using enzyme linked immunosorbent assay, based on samples collected with absorbent paper points inserted into the periodontal pocket for 30 seconds, assessed at baseline before the intervention and at 90 days after non-surgical periodontal treatment with or without antimicrobial photodynamic therapy

—

Countries

Contacts

Public ContactCarlos Sanchez-Ramirez

Facultad de odontología Universidad Central de Venezu

odcarlossanchez@gmail.com+58-412-9454662

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: May 1, 2026