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Do combined non-invasive stimulation techniques affect the brain behavior of individuals with depressive symptoms? A randomized controlled trial

Does combined non-invasive neuromodulation affect cortical metrics in individuals with depressive symptoms? a randomized controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2zbpvx3
Enrollment
Unknown
Registered
2025-12-04
Start date
2025-04-11
Completion date
Unknown
Last updated
2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mental disorder

Interventions

This is a randomized controlled trial with a sample of 84 participants diagnosed with mild or moderate depression, undergoing combined or individual non-invasive neuromodulation for 12 sessions, twice

Sponsors

Universidade Federal De Juíz De Fora - UFJF/GV
Lead Sponsor
Universidade Federal De Juíz De Fora - UFJF/GV
Collaborator

Eligibility

Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: Participants with mild to moderate depressive disorder, aged between 18 and 45 years, duly diagnosed and identified through self-report.

Exclusion criteria

Exclusion criteria: Individuals with epilepsy, using anticonvulsant medication and/or with sleep deprivation; participants with metallic materials implanted in or near the head (examples, cochlear implant, implanted electrodes/stimulators, aneurysm clips or coils, firearm projectile fragments, jewelry and hair clips); participants with pacemakers or cardiac stents or other active devices where interaction with the electric field may interfere with their functioning; participants with eczema on the head.

Design outcomes

Primary

MeasureTime frame
To analyze the clinical responses and cortical metrics to the isolated and combined application of tDCS and taVNS.—

Secondary

MeasureTime frame
Analyze the short-term and late response of isolated and combined application of tDCS and taVNS on depressive symptoms; Analyze the immediate, short-term, and late response of isolated and combined application of tDCS and taVNS on cortical metrics; Analyze the immediate, short-term, and late response of isolated and combined application of tDCS and taVNS on sympathetic/parasympathetic response based on heart rate variability analysis.—

Countries

Brazil

Contacts

Public ContactAlexandre Barbosa

Universidade Federal De Juíz De Fora - UFJF/GV

alexandre.barbosa@ufjf.br+55 (33) 991541851

Outcome results

None listed

Source: REBEC (via WHO ICTRP)