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Artificial ventilation setting in patients infected with COVID-19

Individualized PEEP setting in patients with Acute Respiratory Distress Syndrome: ventilatory strategy in the COVID-19 pandemia

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2z3f7k
Enrollment
Unknown
Registered
2020-05-04
Start date
2020-04-29
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory tract diseases

Interventions

The techniques will be applied to mechanically ventilated individuals in a supine or prone position. All devices and monitors to which the patient is connected will be checked, such as multiparametric
Vt (tidal volume) = 6 ml / kg of predicted weight
PEEP = 10 cmH2O
FR (respiratory rate) = 20 irpm
FiO2 to maintain between 92% and 88% SpO2
Plateau pressure less than 30 cmH2O. Perform a blood gas analysis and adjust the ventilation parameters a
Procedure/surgery
E02.041.625

Sponsors

Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro
Lead Sponsor
Hospital Universitário Pedro Ernesto
Collaborator

Eligibility

Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Age 18 to 80 years; Mechanically ventilated patients with COVID-19 infection suspicious

Exclusion criteria

Exclusion criteria: Pregnancy confirmed by laboratory tests; • Weight below 35 kg; Patients undergoing endotracheal intubation as a result of exacerbation of chronic lung disease; Radiological aspects compatible with pulmonary fibrosis, consolidation of the lung parenchyma, tumor masses and emphysema; Patients with pneumatocele; Pneumothorax, subcutaneous emphysema and pneumomediastinum documented and not resolved; Patients with heart failure previously classified as functional class III or IV according to the New York Heart Association (NYHA); Patients with acute coronary syndrome or persistent ventricular tachyarrhythmias; Mean arterial pressure (MAP) less than 65 mmHg with a dose of norepinephrine 0.5 to 1.0 mg / kg / min; Acute brain injury or high intracranial pressure, that is, greater than 18 mmHg;

Design outcomes

Primary

MeasureTime frame
Comparison of mechanical parameters between table adjustment and decremental titration—

Secondary

MeasureTime frame
To evaluate the effects of individualized PEEP adjustment on gas exchange in patients with ARDS infected with COVID-19. ;Time of mechanical ventilation;Incidence of pneumothorax;Intrahospital mortality—

Countries

Brazil

Contacts

Public ContactTiago Xavier

Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro

tiago.xavier@ifrj.edu.br+55-21-99270-0390

Outcome results

None listed

Source: REBEC (via WHO ICTRP)