DNA damage of residents in anesthesiology during the period of residence
Conditions
Interventions
Monitoring semiannual of the subjects by venous blood.
Experimental group: 30 medical residents occupationally exposed to residues of inhaled anesthetics, the beginning of the residence at the end of
Other
Sponsors
Departamento de Anestesiologia
Faculade de Medina de Botucatu - UNESP
Eligibility
Inclusion criteria
Inclusion criteria: First year of medical residency in anesthesiologists areas; general surgery; orthopedics; neurosurgery; healthy volunteers; both genders; aged 18 to 35
Exclusion criteria
Exclusion criteria: Have done medical residence in the areas of interest of the study; Carrier malignancy; be more than 35 years of age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find increased DNA damage of participants increases as its exposure through the comet assay in lymphocytes analyzed by fluorescence microscopy images with the aid of a software capable of detecting the intensity of the tail, and the higher the greater the tail damage, besides biochemical and hormonal results and oxidative stress test directly related to DNA damage. We also expect information of anesthetic gases residue concentrations in the operating room to operating rooms still without adequate exhaust system and renewal of air and its possible effects compared to rooms with adequate exhaust system. The results in all tests are comparative between the exposed and control groups for significant difference check. | — |
Secondary
| Measure | Time frame |
|---|---|
| Are not expected. | — |
Countries
Brazil
Contacts
Public ContactAline Aun
Faculade de Medina de Botucatu - UNESP
Outcome results
None listed