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Mild ovarian stimulation: lowest cost in vitro fertilization protocol to serve couples with difficulty to get pregnant at Hospital das Clínicas da USP

Minimal Ovarian Stimulation: Low Cost In Vitro Fertilization Protocol for Infertile Couples at a University Center for Human Reproduction

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2xxcvqj
Enrollment
Unknown
Registered
2024-04-03
Start date
2018-07-26
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infertility

Interventions

Randomization was performed using the R computer program before the start of the stimulus. The groups were matched by patient age ( 35 years), BMI (> or = 25 and or = 3 years and < 3 years). As it wa
E02.875.800.984

Sponsors

Hospital das Clínicas da Universidade Federal de São Paulo
Lead Sponsor
Hospital das Clínicas da Universidade Federal de São Paulo
Collaborator

Eligibility

Sex/Gender
Female
Age
No minimum to 38 Years

Inclusion criteria

Inclusion criteria: women aged up to 38 years; body mass index (BMI) up to 30 kg/m²; FSH dosage less than 10 mUI/ml; antral follicle count in the initial follicular phase higher than 5 follicles

Exclusion criteria

Exclusion criteria: sperm collection performed by any method other than masturbation, such as epididymal or testicular puncture; couples who did not agree with the Informed Consent Form (TCLE)

Design outcomes

Secondary

MeasureTime frame
Expected result 2: To compare the implantation rate, miscarriage, multiples per initiated cycle in infertile couples undergoing in vitro fertilization treatment with conventional ovarian stimulation protocol and ovarian stimulation with low doses of gonadotropins. We expect to observe similar results between the study group (low-dose gonadotrophin ovarian stimulation protocol) and the control group (conventional ovarian stimulation protocol).;Outcome found 2: In this study there was no statistical difference between the groups for implantation rate, multiple pregnancy rate and miscarriage rate—

Primary

MeasureTime frame
Expected outcome 1: To compare the pregnancy rate per transfer and per initiated cycle in infertile couples undergoing in vitro fertilization treatment with a conventional ovarian stimulation protocol and ovarian stimulation with low doses of gonadotropins. It is expected that the study group (low-dose gonadotrophin ovarian stimulation protocol) will be non-inferior compared to the control group (conventional ovarian stimulation protocol).;Outcome found 1: In this study there was no statistical difference between the groups for clinical pregnancy rate per transfer and cumulative: control group (24% and 34%) versus minimal stimulation group (27% and 30%); p = 0.729 and 0.726) respectively.—

Countries

Brazil

Contacts

Public ContactMayra Nakano

Hospital das Clínicas da Faculdade de Medicina da USP

mayra.nakano@gmail.com+5511985249093

Outcome results

None listed

Source: REBEC (via WHO ICTRP)