Gastric neoplasms Colorectal neoplasms Anus neoplasms Non-Small-Cell Lung carcinoma Intestinal neoplasms
Conditions
Interventions
Intervention: 3.6 g/day of the encapsulated fish oil (2 capsules/day) providing 1.55 g/d of the n-3 polyunsaturated fatty acids (EPA and DHA) during 9 weeks. Number of subjects expected: 20
Placebo: 3
Dietary supplement
Sponsors
Universidade Federal de Santa Catarina - UFSC
Centro de Pesquisas Oncológicas de Florianópolis - CEPON/SC
Eligibility
Age
19 Years to No maximum
Inclusion criteria
Inclusion criteria: Individuals with 19 years or older, histopathologic diagnosis of gastric cancer, or colorectal or anal canal or non-small cell lung cancer, ability to start chemotherapy in co-participant institution (CEPON).
Exclusion criteria
Exclusion criteria: Prior chemotherapy, inability to oral intake, diagnosis of infectious or inflammatory disease, be allergic to fish and / or derivatives, be pregnant, treatment with statins, ??use of fish oil and/or another supplement containing omega-3 or other polyunsaturated fatty acid in the six months prior to the study period, continued use of supplements containing antioxidants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decrease in levels of inflammatory markers (TH1 response cytokines - IL-2, IL-4, IL-6, TNF, IFN-y, IL-17A, IL-10) and prostaglandin E2 (PGE2), from quantification of the plasma levels of these biomarkers before (baseline), 5 weeks and after (9 weeks) fish oil supplementation, using ELISA technique of quantification, and comparing with levels of control group;Increased activity of antioxidant enzymes (catalase, glutathione peroxidase and superoxide dismutase) verified through spetophotometric assays in erythrocytes before supplementation and after nine weeks of supplementation with fish oil and comparing with activity of enzymes in control group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Decrease in levels of acute phase protein (CRP, albumin, transferrin and pre-albumin), from quantification of the serum levels of these biomarkers before (baseline), 5 weeks and after (9 weeks) fish oil supplementation, and comparing with levels of control group;Improvement of global quality of life. For assessment of this outcome, will be used specific questionnaires for cancer patients, created by EORTC group: QLQ-C30 version 3.0, CRC-29 e STO 22. The questionnaires have scales with four points, and, to find the expected outcome, will be considered a variation at least 10 points in the overall score for each questionnaire used, before and after treatment, and comparing with the control group;maintenance or improvement of the nutritional status. To establish the nutritional status will be assessed weight, height, arm circumference (AC) and triceps skinfold (TS), and, calculated the BMI and AC/TS adequation. To find the outcome expected, will be considered the values of each variable before, during and after fish oil treatment and compared with the values from control group;Maintenance or improvement of the body composition. To verify the body composition will be estimated the percentage of fat mass and free fat mass by using a electric bioimpedance. To find the outcome expected, will be considered the values of each variable before and after fish oil treatment and compared with the values from control group;Increased lipid peroxidation. Verified by quantification of lipid hydroperoxides by FOX2 method in plasma and leukocytes before and after nine weeks of supplementation with fish oil and compared to the concentrations of lipid hydroperoxides found in control group.;Improvement of clinical prognosis. Assessed by grading of adverse events related to chemotherapy, delays in the administration of chemotherapy, incidence of hospitalization or treatment discontinuation due to adverse events, number of chemotherapy cycles performed during the period before and after ni | — |
Countries
Brazil
Contacts
Public ContactErasmo;Everson Trindade;Nunes
Universidade Federal de Santa Catarina - UFSC;Universidade Federal de Santa Catarina - UFSC
Outcome results
None listed