COVID-19
Conditions
Interventions
This is an open-label, non-randomized, four-arm clinical trial. One-hundred normotensive men and 100 hypertensive, between the ages of 35 and 55 years-old, all affected by SARS-COVID19 between 6 and 2
group B, who experienced major symptoms, but not hospitalization
group C, mild symptoms
group D, assymptomatic.
Intervention: All groups will be enrolled into a supervised 16-week aerobic physical trainning program with one hour sessions, 3 times per week on a motorized treadmill. Durin
Sponsors
Faculdade de Medicina de Ribeirão Preto - FMRP/USP
Faculdade de Medicina de Ribeirão Preto - FMRP/USP
Eligibility
Sex/Gender
Male
Age
35 Years to 55 Years
Inclusion criteria
Inclusion criteria: Homens; hipertensos ou normotensos; idade entre 35 e 55 anos; acometidos por COVID-19 entre 6 e 24 meses antes; assintomático, leve ou internados em enfermaria por baixa saturação de oxigênio
Exclusion criteria
Exclusion criteria: Smokers; diagnosis of cognitive disturbances, musculoskeletal disorders, and chronic diseases; during the period of transmission of the Covid-19 disease; patients who had the severe form and required ICU admission; previous home or outpatient physical therapy treatment; current use of drugs that interfere with cardiac functionality and cardiovascular autonomic control
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypertensive men and women, without comorbidities, affected by Covid-19, who developed the mild, moderate or severe form of the disease, may present increased sympathetic influence and decreased parasympathetic activity when evaluated through spectral analysis of heart rate and compared conditions pre and post the aerobic physical training program.;It is expected to find metabolic alterations, evaluated through blood samples, such as: increase in fasting glucose and insulin; increase in total cholesterol and fractions; increase in triglycerides; increase in C-reactive creatine; increased levels of tumor necrosis and interleukins (IL-6 and IL-10). All these variables are influenced by the aerobic physical training program. | — |
Secondary
| Measure | Time frame |
|---|---|
| The aerobic physical training program may be able to promote in all men affected by covid-19, from the four groups studied, the improvement of cardiorespiratory and metabolic function, such as the anaerobic threshold and volume of oxygen consumed at peak exercise (VO2peak) , evaluated by means of the ergospirometric test.;The aerobic physical training program may also be able to promote different cardiac hemodynamic and autonomic effects, decrease inflammatory markers, in addition to improving skeletal muscle strength and functionality, which may provide benefits for physical and mental health. | — |
Countries
Brazil
Contacts
Public ContactHugo;Ana Souza;Veiga
Faculdade de Medicina de Ribeirão Preto - FMRP/USP;Faculdade de Medicina de Ribeirão Preto - FMRP/USP
Outcome results
None listed