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Angiotensin-(1-7) oral formulation improves physical performance in mountain bike athletes

Effect of the oral formulation Hpbcd / Angiotensin- (1-7) in the treatment of muscle microlesion induced by sports practice

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2x56pw8
Enrollment
Unknown
Registered
2021-01-11
Start date
2016-08-03
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Performance-Enhancing Substances

Interventions

The distribution of the supplement was double-blinded and randomized. Participants received either the formulation of HPß-CD-Placebo (n=21) or the HPß-CD-Ang-(1-7) (n=21) (1.75 mg), 50% of subjects ra
D000809

Sponsors

Grupo de pesquisa em Mecanofisiologia
Lead Sponsor
Universidade Federal de Ouro Preto
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: healthy volunteers; of both genders; older than 18 years; impeded in their cycling training programs for at least 12 months; conduct at least four MTB training schools per week.

Exclusion criteria

Exclusion criteria: make use of supplements with a potential stimulating effect on the cardiovascular system (such as caffeine and guarana powder); history of current injuries or in the last six months; not willing to abstain from intense exercise 24 hours before the test

Design outcomes

Primary

MeasureTime frame
The oral formulation of HPß-CD-Angiotensin- (1-7) (1.75 mg) improved the physical performance of MTB athletes submitted to a progressive load protocol until voluntary fatigue in a leg cycle ergometer, since it promoted an increase maximum oxygen consumption (+6 mlo2.kg-1.min-1 in supplemented condition) assessed by ergospirometry (vo2000), a longer total exercise time (+60 seconds in supplemented condition);The oral formulation of HPß-CD-Angiotensin- (1-7) (1.75 mg) improved the physical performance of MTB athletes submitted to a progressive load protocol until voluntary fatigue in a leg cycle ergometer, since it promoted less subjective perception of effort (assessed using the Borg scale) (- 3pts). There was no difference in cardiovascular parameters (BP and HR) between placebo and the condition treated at rest or at peak physical effort.

Countries

Brazil

Contacts

Public ContactSamara de Moura
samara_silva09@hotmail.com+55313559-1518

Outcome results

None listed

Source: REBEC (via WHO ICTRP)