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Evaluation of control of signs and symptoms of inflammation after third molar extraction

Evaluation of pain control, edema and trismus after third molar extraction through two pharmacological regimens

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-2x2ntz
Enrollment
Unknown
Registered
2019-01-04
Start date
2017-03-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Inflammation

Interventions

Split-mouth study, third-molar extraction, administration of intramuscular dexamethasone, administration of oral etoricoxib In this study, 19 healthy patients with bilateral third molars bilaterally i
Drug
E06.892
D04.210.500.745.432.769.344
D27.505.519.389.310.500

Sponsors

Universidade Federal do Piauí
Lead Sponsor
Universidade Federal do Piauí
Collaborator
Éwerton Daniel Rocha Rodrigues
Collaborator
Empresa Brasileira de Serviços Hospitalares - EBSERH
Collaborator

Eligibility

Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: age between 18 and 35 years; no systemic disease (ASA I); not to use medications currently or in the previous week of the research; To present the lower third molars in similar positions with similar patterns of root formation; do not present allergy to the drugs used in the study; To present surgical site without current signs and symptoms of infection

Exclusion criteria

Exclusion criteria: patients with a history of pregnancy or lactation; history of gastrointestinal bleeding or peptic ulcer; allergy to aspirin or NSAIDS; liver, kidney, haematological and central nervous system diseases; continued use of psychoactive drugs, analgesics, steroidal and non-steroidal anti-inflammatory drugs and smokers.

Design outcomes

Primary

MeasureTime frame
The aim of this study is to evaluate whether dexamethasone has a greater efficacy in the control of pain, edema and trismus in relation to etoricoxib after third molar extraction. Verified by visual analog scale in 7 days (pain), measurement of 5 facial measures in the preoperative and postoperative periods of 72h (edema) and measurement of inter-incisal distance in the preoperative and postoperative periods of 72h (trismus ).;It was observed that dexamethasone was more effective in controlling edema when compared to etoricoxib with p-value = 0.028. There was no statistically significant difference for pain and trismus assessments.—

Secondary

MeasureTime frame
It is expected to evaluate whether dexamethasone is more effective than etoricoxib in controlling trismus after extractions of lower third molars;No difference was observed between dexamethasone and etoricoxib in the control of trismo after exodontia of lower third molars—

Countries

Brazil

Contacts

Public ContactÉwerton Rocha Rodrigues

Universidade de Pernambuco

ewertondaniel27@hotmail.com+55 81 31847659

Outcome results

None listed

Source: REBEC (via WHO ICTRP)