Undernutrition.
Conditions
Interventions
Observational study to assess selenium plasma concentrations and erytrocyte glutathione peroxidase activity in critically ill children, nourished and malnourished, receiving enteral tube feeding. Sam
Other
D01.268.185.850
D12.644.456.448
Sponsors
Universidade Federal de São Paulo - UNIFESP
Fundação de Amparo à Pesquisa do Estado de São Paulo
Eligibility
Age
1 Months to 18 Years
Inclusion criteria
Inclusion criteria: Children admitted to the Pediatric Intensive Care Unit with a diagnosis of systemic inflammatory response syndrome, sepsis, septic shock or multiple organ systems.
Exclusion criteria
Exclusion criteria: Neonates, children with chronic renal or hepatic impairment, and suspected inborn error of metabolism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of requency and risk factors associated with low plasma selenium and glutathione peroxidase activity in red blood cells of critically ill children on admission and on the fifth day of hospitalization in the pediatric intensive care unit, considering the nutritional status and intensity of the inflammatory response. Nutritional status will be assessed by age, weight, height and their relationship on admission. The intensity of the inflammatory response will be assessed by measurement of plasma C-reactive protein on admission and on the fifth day of hospitalization. As a result, it is expected that patients with impaired nutrition (malnutrition) on admission and more intense inflammatory response during hospitalization have a lower plasma selenium concentration compared to patients without malnutrition and lower inflammatory response. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secundary outcomes. | — |
Countries
Brazil
Contacts
Public ContactSimone Iglesias
Universidade Federal de São Paulo - UNIFESP
Outcome results
None listed